Bromfenac ophthalmic solution is indicated for the treatment of postoperative inflammation and for the relief of ocular pain in patients following cataract surgery.

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) with significant anti-inflammatory effects. Its mechanism of action involves inhibition of prostaglandin synthesis through blocking cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins play an important role in mediating intraocular inflammation. Studies in animal models have shown that prostaglandins can disrupt the blood-aqueous barrier, cause vasodilation, increase vascular permeability, promote leukocyte infiltration, and elevate intraocular pressure.

For the treatment of postoperative inflammation in patients who have undergone cataract extraction, one drop of ophthalmic solution should be applied to the affected eye(s) once daily beginning 1 day prior to cataract surgery, continued on the day of surgery, and through the first 14 days of the postoperative period.

Bromfenac ophthalmic solution is contraindicated in patients with known hypersensitivity to any component of the formulation.

Commonly reported adverse effects include abnormal sensation in the eye, conjunctival hyperemia, eye irritation (such as burning or stinging), eye pain, itching, redness, headache, and iritis.

Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. This medication should be used during pregnancy only if the expected benefit outweighs the potential risk to the fetus. Caution is advised when administering Bromfenac ophthalmic solution to breastfeeding women.

Topical NSAIDs may delay or slow the healing process. Topical corticosteroids are also known to have similar effects. Using topical NSAIDs together with corticosteroids may increase the risk of delayed healing. Bromfenac ophthalmic solution should be used cautiously in patients with known bleeding disorders or in those taking medications that may prolong bleeding time.

Ophthalmic Non-Steroid drugs

Store in a cool (below 30°C), dry place away from light. Keep out of reach of children. To avoid contamination, do not touch the dropper tip to the eyelids, surrounding areas, or any surface. Keep the bottle tightly closed when not in use. Do not use the product more than 4 weeks after first opening.