Butenafine cream is indicated for the topical treatment of superficial dermatophyte infections, including:
Butenafine is a synthetic antifungal agent related structurally and pharmacologically to allylamine antifungals. Although its exact mechanism of action is not fully established, it is believed to act by altering fungal cell membranes, increasing membrane permeability and inhibiting fungal growth. Butenafine is particularly effective against dermatophytes and shows strong fungicidal activity compared to agents like terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole.
It is also active against Candida albicans, with activity comparable or superior to terbinafine and naftifine. Additionally, it demonstrates low minimum inhibitory concentrations (MICs) against organisms such as Cryptococcus neoformans and Aspergillus species.
In the treatment of interdigital tinea pedis, Butenafine should be applied twice daily for 7 days or once daily for 4 weeks. Patients with tinea corporis or tinea cruris should apply Butenafine once daily for two weeks. Sufficient Butenafine cream should be applied to cover affected areas and immediately surrounding skin of patients with interdigital tinea pedis, tinea corporis and tinea cruris.
Potential drug interactions with butenafine HCl cream have not been sufficiently studied.
Butenafine Hydrochloride is contraindicated in individuals with known or suspected hypersensitivity to the drug or any of its components.
Occasionally, mild local burning or irritation may occur. Hypersensitivity reactions are also possible.
Pregnancy Category C. Due to the absence of adequate and well-controlled studies, this medication should be used during pregnancy only if clearly necessary. It is not known whether butenafine is excreted in human milk. Therefore, caution should be exercised when administered to nursing mothers.
The safety and effectiveness of butenafine in children under 12 years of age have not been established.
Butenafine cream is intended for external use only and should not be used in the eyes, orally, or intravaginally. If irritation or allergic reaction develops, treatment should be discontinued and appropriate medical care should be initiated.
No cases of overdose with butenafine HCl in humans have been reported to date.
Topical Antifungal preparations
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
What is Butenafine Hydrochloride for?
What does Butenafine Hydrochloride do?
What are the side effects of Butenafine Hydrochloride?
What happens if you use too much Butenafine Hydrochloride?
Can Butenafine Hydrochloride be used during pregnancy?
No available drugs found