Oxiconazole topical preparation is indicated for the treatment of superficial fungal skin infections, including: Tinea pedis, Tinea cruris, Tinea corporis, caused by Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. Oxiconazole cream is also indicated for the treatment of tinea (pityriasis) versicolor due to Malassezia furfur.

This topical preparation contains the antifungal agent Oxiconazole Nitrate and is for external dermatological use only. Oxiconazole Nitrate is an imidazole derivative whose antifungal activity is mainly due to inhibition of ergosterol biosynthesis, which is essential for fungal cell membrane integrity. It has in vitro and clinical activity against a wide range of pathogenic fungi. Oxiconazole is active against organisms including Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, and Malassezia furfur. It also shows inhibitory activity (MIC values) against Microsporum audouini, Microsporum canis, Microsporum gypseum, Trichophyton tonsurans, and Trichophyton violaceum.

This topical preparation should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Oxiconazole Cream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.

• Use Oxiconazole topical preparation as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Oxiconazole cream is for external use only.
• Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks or sooner if the condition worsens.
• Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.
• Avoid the use of occlusive dressings unless otherwise directed by the physician.
• Do not use this medication for any disorder other than that for which it was prescribed.

Potential drug interactions between Oxiconazole and other drugs have not been systematically evaluated.

Oxiconazole topical preparation is contraindicated in individuals who have shown previous hypersensitivity to Oxiconazole.

Possible side effects include pruritus, burning sensation, irritation, allergic contact dermatitis, folliculitis, erythema, papules, fissures, skin maceration, rash, stinging, and nodules.

Pregnancy Category B. Since Oxiconazole Nitrate is excreted in human milk, caution should be taken when administering it to a nursing mother.

Oxiconazole topical preparation is not intended for ophthalmic or intravaginal use.

Topical antifungal preparations.

Store in a cool and dry place, protected from light. Do not freeze.