Oxybuprocaine is used to temporarily numb the front surface of the eye, allowing procedures such as measuring intraocular pressure or removing a foreign body from the eye.

Oxybuprocaine is a local anesthetic agent used in ophthalmic practice. It may be less irritating than tetracaine, while having a similar onset and duration of action. It works by binding to sodium channels and reversibly stabilizing neuronal membranes, thereby reducing sodium ion permeability. This inhibition prevents depolarization of nerve membranes and blocks the initiation and conduction of nerve impulses, producing local anesthesia.

Use as a 0.4% solution in short ophthalmic procedures. Instil 1 drop into the conjunctival sac to allow tonometry after 60 sec; a further drop after a 90 sec interval produces sufficiReduce systemic absorption by compressing the lacrimal sac at the medial canthus for a minute during and following instillation. Heart block; epilepsy, impaired cardiac conduction, myasthenia gravis; not to be applied to inflamed, infected tissues or damaged mucosa. Protect anaesthetised eye from dust and bacterial contamination; cornea may be damaged by prolonged application. Do not drive until normal vision restored.ent anaesthesia for the fitting of contact lenses; 3 drops at 90 sec intervals produces sufficient anaesthesia after 5 min for a foreign body to be removed from the corneal epithelium or for incision of a meibomian cyst through the conjunctiva.

Possible side effects include hypersensitivity reactions, transient stinging, temporary blurred vision, central nervous system stimulation, muscle twitching, tremors, and convulsions.

Pregnancy Category C. Animal studies have shown adverse effects on the fetus (including teratogenic or embryocidal effects), and there are no well-controlled studies in pregnant women. The drug should be used only if the potential benefit justifies the potential risk to the fetus.

Systemic absorption should be reduced by pressing the lacrimal sac at the medial canthus for one minute during and after instillation. Use with caution in patients with heart block, epilepsy, impaired cardiac conduction, and myasthenia gravis. It should not be applied to inflamed, infected, or damaged mucosal tissues. The anesthetized eye should be protected from dust and bacterial contamination, and prolonged use may damage the cornea. Patients should avoid driving until normal vision is restored.

Ocular perioperative drugs.