Oxymetazoline Hydrochloride is indicated for the relief of nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, upper respiratory tract allergies, epistaxis, and hay fever. It is also used as a nasal decongestant in otitis media.

Oxymetazoline Hydrochloride is an imidazoline derivative sympathomimetic amine. It acts as a direct agonist at alpha-adrenoceptors and has no activity on beta-adrenoceptors. When applied to the nasal mucosa, it produces rapid and long-lasting vasoconstriction of arterioles, reducing blood flow and decreasing mucosal swelling. This leads to improved airway patency and better sinus drainage.

Oxymetazoline nasal spray

• Adults and children (6 years of age and older): 2 or 3 sprays in each nostril twice daily for 3–5 days.
• Elderly: There is no need for dosage reduction in the elderly for nasal administration.
• Children below 6 years of age: It is not suitable for children below 6 years of age.

Oxymetazoline nasal drop

• Adults & children 6 years of age: 2–3 drops of 0.05% Nasal Drops in each nostril twice daily in the morning and evening.
• Children 2–5 years of age: 2–3 drops of 0.025% Nasal Drops in each nostril twice daily in the morning and evening.

How to use the Nasal Spray-

• Shake the bottle gently and remove the dust cover.
• Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine mist comes out from the container.
• Gently blow the nose to clear the nostrils.
• Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white-collar of nasal applicator firmly down once to release a spray.
• Breathe out through your mouth.
• Repeat the above steps in the same/other nostril for consecutive doses.

Cleaning: The nasal spray should be cleaned at least once a week. The procedures are as follows:

• Remove the dust cover.
• Gently pull off the nasal applicator.
• Wash the applicator and dust cover in warm water.
• Shake off the excess water and leave to dry in a normal place. Avoid applying additional heat.
• Gently push the applicator back on the top of the bottle and re-fix the dust cover.

Oxymetazoline Hydrochloride nasal preparation should not be used in patients receiving MAO inhibitors or within 14 days after stopping such treatment.

It is contraindicated in patients with cardiovascular disease, hyperthyroidism, prostatic enlargement, angle-closure glaucoma, and hypersensitivity to any of its ingredients.

Occasionally it may cause local irritation and dryness of the mouth and throat. Temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge may also occur.

The safety of Oxymetazoline Hydrochloride nasal spray during pregnancy and lactation has not been fully established, but it is not considered to pose a known hazard during these periods.

Avoid contact with eyes. The spray should not be used for more than seven days without medical advice. Frequent or prolonged use may lead to rebound nasal congestion or worsening of symptoms.

Overdose may cause local irritation and rebound congestion. Treatment is mainly symptomatic and supportive.

Nasal antihistamine preparations, nasal decongestants & other nasal preparations.

Store below 30°C in a dry place, protected from light. Do not refrigerate or freeze. Keep out of reach of children.