Ketoprofen is indicated for Cattle:

• Treatment of lameness of traumatic origin, fractures, tendonitis, etc.
• Management of post-surgical pain, relieving chronic pain (e.g., arthritis, etc.) and for the symptomatic treatment of fever (e.g., ephemeral fever, FMD, etc.)
• Reducing pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy
• Reducing edema of the udder associated with calving
• Improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis caused by gram-negative bacteria, in conjunction with antimicrobial therapy
• Supportive treatment of parturient paresis (Milk Fever) associated with calving

Ketoprofen is indicated for Horse:

• Alleviation of inflammation and pain associated with musculoskeletal disorders
• Alleviation of visceral pain associated with colic

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic actions. In addition to the inhibition of prostaglandin synthesis, it stabilizes lysosomal membranes in vitro and in vivo, inhibits leukotriene synthesis in vitro at high concentrations, and also exhibits antibradykinin activity in vivo. Ketoprofen produces analgesia by inhibiting the synthesis of prostaglandins peripherally and centrally. It has also been suggested that Ketoprofen causes the suppression of prostaglandin synthesis in the CNS (probably in the hypothalamus) leading to its antipyretic effect.

Injection-

Cattle:

• For deep intramuscular or intravenous use. 1 ml/33 kg body weight (3 mg/kg body weight) once daily for 3 days.

Horse:

• For musculoskeletal disorder: 1 ml/45 kg body weight (2.2 mg /kg) by intravenous injection once daily for 3 to 5 days.
• For equine colic: 1 ml/45 kg body weight (2.2 mg/kg) by intravenous injection. A second injection may be given if colic recurs.

Bolus-

• Cattle: 1 bolus per 100 kg body weight (4 mg/kg) orally daily for upto 3 days. Or As directed by the Veterinary physician.

Concurrent administration with nephrotoxic drugs should be avoided.

Do not administer to cattle or horses hypersensitive to ketoprofen. Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other. Contraindicated in animals suffering from cardiac, hepatic or renal disease, gastrointestinal ulceration or bleeding, and where there is evidence of a blood dyscrasia.

Like all NSAIDs, gastric or renal intolerance may occur in certain individuals.

Ketoprofen may be given to pregnant and lactating cows. Ketoprofen should not be administered to pregnant mares.

Administration in animals aged less than 6 weeks or in aged animals may involve additional risk. In such cases, if treatment is needed, it may require a reduced dosage and careful management. Avoid use in any dehydrated, hypovolemic or hypotensive animals as there is a potential risk of increased renal toxicity.

Withdrawal period: Meat: 4 days, Milk: Nil.

Store below 25°C in a cool & dry place. Protect from light. Keep out of reach of children.