Capsaicin is used for the symptomatic relief of pain associated with osteoarthritis and rheumatoid arthritis.

The exact mechanism of action of capsaicin is not completely established. However, it is known to produce analgesic effects by depleting and preventing the reaccumulation of Substance P in peripheral sensory neurons. Substance P plays a key role in transmitting pain signals from peripheral tissues to the central nervous system.

Systemic absorption following topical application is not clearly known. Capsaicin naturally occurs in capsicum fruits at approximately 1% concentration. Estimated dietary intake ranges from 0.5–1 mg/kg/day for an average adult. Topical application of 90 g of 0.025% capsaicin cream results in an estimated daily exposure of about 3.21 mg. Assuming complete absorption in a 50 kg individual, this corresponds to approximately 0.064 mg/kg/day, which is significantly lower than dietary intake levels.

18 years of age and older: Apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.

Capsaicin cream should not be applied to broken, damaged, or irritated skin. It is also contraindicated in individuals with known hypersensitivity to capsaicin or any of the formulation’s components.

A temporary burning or stinging sensation may occur at the beginning of treatment, especially if excessive amounts are used or if applied less frequently than recommended (less than 3–4 times daily). This sensation usually subsides after a few days of continued use.

The safety of capsaicin use during pregnancy and lactation has not been fully established in humans or animals. However, due to minimal systemic absorption from topical use, it is unlikely to cause harmful effects.

Avoid taking hot baths or showers immediately before or after applying capsaicin, as this may intensify the burning sensation. Wash hands thoroughly after application. Do not use under occlusive (tight) dressings.

Topical Analgesics, Topical anti-inflammatory preparations

Store below 30°C in a cool, dry place away from light and moisture. Keep out of the reach of children.