L-Ornithine L-Aspartate is indicated for the treatment of hepatic encephalopathy, acute liver failure, hyperammonemia due to acute and chronic hepatitis, fatty liver, alcoholic liver damage, as an adjunct to hepatotoxic drugs, liver cirrhosis, post-hepatitis convalescence, etc.

L-Ornithine L-Aspartate is a stable combination of two important endogenous amino acids, L-ornithine and L-aspartate. After administration, it quickly breaks down into L-ornithine and L-aspartate. L-ornithine, being a substrate of the urea cycle, converts toxic ammonia into non-toxic urea, which is eliminated via the kidneys, helping the diseased liver to carry out its normal function smoothly (detoxification). This process lowers the elevated level of ammonia in the blood (hyperammonemia), which is a common problem in most liver diseases. L-aspartate is an essential component of the citric acid cycle, which liberates energy (ATP), and thus helps in the regeneration of damaged liver cells.

Sachet: 1-2 sachets granules is dissolved in a large amount of fluid (e.g. in a glass of water or juice) and is taken orally 3 times a day during or after meals.

Injection (Infusion Concentrate): The recommended dose is up to 20 gm (4 ampoules daily). In case of loss of consciousness (pre-coma) and clouding of consciousness (coma) up to 8 ampoules within 24 hours, depending on the severity of the condition.

AdministrationsL-

• Ornithine L-Aspartate infusion concentrate can be added to any of the conventional intravenous fluids (0.9% Sodium Chloride, 5% Dextrose and Ringer's lactate etc.)
• The normal dilution rate is 1 ampoule per 100 ml of I.V. fluid. However, the dose should not exceed 6 ampoules per 500 ml infusion. The solution mixtures were stable up to 24 hours.
• Infusion Rate: 5 gm/h at maximum.

No data regarding the interactions of L-Ornithine L-Aspartate were found.

Very rarely, side effects like nausea and vomiting occur. These side effects are usually transient and do not necessitate the withdrawal of the drug.

Administration during pregnancy and lactation should be avoided.

Monitoring of serum and urinary urea levels at regular intervals should be performed.

Digestive Enzyme

Store in a cool and dry place, keep away from light.