This oral solution is indicated in the following conditions:

• To relieve discomfort in urinary tract infections
• To help prevent kidney stones
• To be used with uricosuric agents for the prevention of gout
• Acidosis caused by kidney diseases

This oral solution is an effective alkalinizing agent used in conditions where long-term maintenance of alkaline urine is required, such as in patients with uric acid and cystine stones in the urinary tract, especially when sodium salts are not suitable or are contraindicated. It is also a useful supportive treatment when given with uricosuric agents in gout therapy, as urates tend to crystallize in acidic urine. It is effective in correcting acidosis in certain renal tubular disorders where potassium citrate may be preferred. This product is highly concentrated and, when taken after meals and before bedtime, helps maintain an alkaline urinary pH throughout the day and night, usually without the need for a 2 A.M. dose. It alkalinizes the urine without causing systemic alkalosis when used at the recommended dose. It has a pleasant taste, is easy to take, and is well tolerated even during long-term use. Potassium Citrate does not neutralize gastric juice or disturb digestion.

Potassium Citrate is absorbed and metabolized into potassium bicarbonate, which acts as a systemic alkalizer. Its effects are mainly like chlorides before absorption and like bicarbonates after absorption. Oxidation is almost complete, so less than 5% of unchanged potassium citrate is excreted in the urine.

Oral Solution should be taken diluted in water according to directions, followed by additional water, if desired. Palatability is enhanced if chilled before taking. Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations.

To relieve discomfort in UTI:

• Adults and children over 6 years: 10 ml 3 times daily, diluted with 1 glass of water.
• Children 1–6 years: 5 ml 3 times daily, diluted with ½ glass of water.

To prevent kidney stones, With a uricosuric agent to prevent gout, Acidosis caused by kidney diseases:

• Adults: 10–15 ml 4 times daily (or as directed by the physician) diluted with 1 glass of water.
• Pediatric: 5–10 ml 4 times daily (or as directed by the physician) diluted with ½ glass of water.

Concurrent use of potassium-containing medicines, potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, or cardiac glycosides may increase the risk of toxicity.

This medicine is contraindicated in patients with severe renal impairment accompanied by oliguria or azotemia, untreated Addison’s disease, acute dehydration, severe myocardial damage, and hyperkalemia from any cause.

This solution is generally well tolerated when used in recommended doses in patients with normal kidney function and urine output. However, caution is required in patients with impaired renal function to avoid hyperkalemia or alkalosis. Potassium intoxication may cause symptoms such as weakness, fatigue, mental confusion, tingling sensation in extremities, and other effects related to high serum potassium levels.

There are no sufficient data on the use of Potassium Citrate oral solution in pregnant women. Animal studies are inadequate regarding effects on pregnancy. The potential risk to humans is unknown. Therefore, it should be used during pregnancy only if clearly necessary and under medical supervision.

This solution should be used carefully in patients with low urinary output. It should be adequately diluted with water to reduce the risk of gastrointestinal irritation caused by concentrated potassium solutions. Each dose should preferably be taken after meals.

High doses may lead to hyperkalemia and alkalosis, especially in patients with kidney disease.

Caution is required when used with potassium-containing drugs, potassium-sparing diuretics, ACE inhibitors, or cardiac glycosides, as toxicity may occur. Do not exceed the recommended dose and discontinue if adverse reactions occur.

In individuals with normal potassium excretion, oral potassium rarely causes severe hyperkalemia. However, if kidney function is impaired, dangerous hyperkalemia may develop rapidly and must be treated immediately. Symptoms may include weakness, irregular heartbeat, and ECG changes. Severe cases can be life-threatening within hours. Treatment includes: Stopping potassium intake from food and medicines, Intravenous dextrose with insulin infusion, Use of exchange resins, Hemodialysis or peritoneal dialysis if required.

Prevention of repeated kidney stone formation, Urinary alkalinizing agent

Keep below 30°C, protect from light and moisture. Keep out of reach of children.