Clindamycin and Tretinoin gel is indicated for the topical treatment of acne vulgaris.

This formulation combines the lincosamide antibiotic clindamycin phosphate with the retinoid tretinoin. Clindamycin binds to the 50S subunit of susceptible bacterial ribosomes, inhibiting peptide chain elongation by interfering with peptidyl transfer, thereby suppressing bacterial protein synthesis. It also reduces the activity of Propionibacterium acnes, helping to control acne. Tretinoin reduces the cohesiveness of follicular epithelial cells and increases cellular turnover, promoting the expulsion of comedones.

Before sleep: Wash the face gently with a mild soap and water, then pat the skin dry. Apply the Gel with finger tips through the face gently.

In the morning: Apply a sunscreen after the application of Gel. Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed.

Safety and effectiveness in children below 12 years of age have not been established.

• Concomitant use with other potentially irritating topical products (such as medicated or abrasive soaps, strong cleansers, cosmetics with drying effects, or products containing high concentrations of alcohol, astringents, spices, or lime) should be approached with caution.
• Concurrent use with erythromycin may reduce the effectiveness of both clindamycin and erythromycin; therefore, they should not be used together.
• When used with neuromuscular blocking agents, their effects may be enhanced; caution is advised during such combined use.

Clindamycin and Tretinoin gel should not be used in individuals with known hypersensitivity to clindamycin, tretinoin, or any of the formulation components.

Common side effects include erythema, scaling, nasopharyngitis, dry skin, cough, sinusitis, and diarrhea.

It is not known whether clindamycin or tretinoin is excreted in human breast milk. Therefore, caution should be exercised when applying this medication to nursing mothers.

Clindamycin and Tretinoin should not be applied to the eyes, nose, ears, lips, cuts, burns, or infected skin areas. After application, exposure to sunlight should be avoided.

Topical antibiotic & retinoid preparations

Store below 25°C, protected from light and moisture. Keep out of reach of children.