This combination IV infusion is indicated for:

• Cholera
• Diarrhea
• Severe vomiting
• Fluid loss due to excessive sweating

Each 100 ml solution contains:

• Sodium Chloride 0.9% BP 0.5 gm
• Potassium Chloride BP 0.1 gm
• Sodium Acetate BP 0.393 gm

Sodium plays a key role in regulating total body water and its distribution. It is the major cation in extracellular fluid, accounting for more than 90% of total cations. The acetate component serves as an alternative source of bicarbonate through metabolic conversion in the liver. Potassium chloride is the major intracellular cation and plays an important role in nerve impulse transmission to the heart, brain, and skeletal muscles. It is also essential for muscle contraction, maintenance of renal function, acid–base balance, carbohydrate metabolism, and gastric secretion. Sodium Chloride 0.9% is the principal extracellular electrolyte, essential for fluid balance, osmotic pressure regulation, and water distribution. It helps maintain hydration and is used in the treatment of metabolic acidosis, as an initial solution in hemodialysis, and in hyperosmolar diabetes. It is also used as a vehicle for compatible intravenous drug additives.

The amount and rate of infusion will depend on the patient's requirements and the physician's judgment. It usually varies with age, weight and clinical condition of the patient. Recommended flow rate is 100-drop/min/up to 70 kg body weight.

Potassium chloride: May interact with potassium-sparing diuretics, ACE inhibitors, cyclosporine, and other potassium-containing drugs.

Antimuscarinics: Delay gastric emptying, increasing the risk of gastrointestinal adverse effects with solid oral dosage forms.

Sodium Chloride 0.9%: May affect serum lithium concentrations.

Sodium acetate: May alter absorption of certain drugs due to increased gastric pH. Acidic drugs (e.g., salicylates, barbiturates) may have increased renal clearance, while basic drugs may have prolonged half-life.

Kidney failure with reduced urine output (oliguria) or complete absence of urine (anuria).

Reactions related to the solution or infusion technique may include fever, infection at injection site, venous thrombosis or phlebitis, extravasation, and hypervolemia. Other symptoms may include burning, pain or swelling at IV site, redness, discharge, bleeding, fever, and persistent cough.

It should not be administered rapidly or for prolonged periods. Since the solution contains multiple electrolytes, it should be used with caution in patients with electrolyte imbalance risks, such as pregnancy, renal impairment, heart failure, pulmonary congestion, or in patients receiving potassium therapy.

Electrolyte preparations

Store below 30°C, away from light and moisture. Keep out of reach of children.