Clotrimazole vaginal preparation is used for the treatment of vaginal itching, burning, and discharge associated with recurrent vaginal yeast infections (vaginal candidiasis). It is also indicated in vaginitis caused by Candida species and other mycotic infections involving organisms sensitive to this medication.

Clotrimazole is a broad-spectrum antifungal agent used in the treatment of infections caused by dermatophytes, yeasts, moulds, and certain bacteria. It is also effective against some gram-positive bacteria, particularly Staphylococci, and organisms like Trichomonas. Similar to other imidazoles, it alters the permeability of fungal cell membranes by interfering with cell wall lipids. At lower concentrations, it inhibits ergosterol synthesis, while at higher concentrations it can directly damage the cell membrane through additional mechanisms.

Clotrimazole 100 mg & 200 mg vaginal preparation–

• First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Clotrimazole 200 mg vaginal preparation is inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent.
• Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Clotrimazole 100 mg vaginal preparation is inserted as deeply as possible into the vagina. If necessary, 2 Clotrimazole 100 mg (1 in the morning and 1 in the evening) or 1 Clotrimazole 200 mg daily can be used for 6–12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Clotrimazole cream at the same time.

Clotrimazole 500 mg vaginal preparation:

• Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent.
• It is recommended that the treatment should be timed so as to avoid the menstrual period.
• For prevention of re-infection the partner should be treated locally with Clotrimazole cream at the same time.

Clotrimazole vaginal preparation are colorless and do not stain the underwear.

Administration

• Pull out plunger until it stops. Place a vaginal tablet into the applicator
• Insert applicator containing the tablet carefully as deeply as possible into the vagina (best lying on your back)
• Push plunger until it stops, thereby depositing the tablet into the vagina. Remove the applicator
• After use, remove plunger completely by pulling it out of the applicator
• Then wash it in warm (not boiling) soapy water, rinse and dry carefully

Note: Pregnant women must follow physician's instructions

No interaction data is available.

It should not be used in patients who have known hypersensitivity to any of the components of this product.

Since clotrimazole is minimally absorbed through the vaginal mucosa, systemic side effects are unlikely. It is generally well tolerated, although mild local irritation or a burning sensation may occasionally occur, which is usually not harmful.

Clotrimazole should be used during pregnancy only when clearly necessary and under medical supervision. It is poorly absorbed into the bloodstream after topical or vaginal application. Studies in women during the second and third trimesters have not shown harmful effects. It is not known whether clotrimazole is excreted in breast milk. Vaginal suppositories may be used during pregnancy, but only under a physician’s guidance.

Drugs used in vaginal and vulval conditions, Topical Antifungal preparations

Store below 25°C, protected from light and moisture. Keep out of reach of children.