Thiamine is specifically used in the treatment of the various manifestations of thiamine deficiency, such as beriberi and Wernicke's encephalopathy, neuritis associated with pregnancy, and pellagra. Supplementary thiamine may be indicated prophylactically in conditions where there is low dietary intake or impaired gastrointestinal absorption of thiamine (e.g., alcohol), or where requirements are increased (pregnancy, carbohydrate-rich diet).

Thiamine Hydrochloride (Vitamin B1) is an essential constituent for the metabolism of carbohydrates and a number of amino acids. Utilization of pyruvic acid and amino acids in tissues is decreased in thiamine deficiency. As a result, pyruvic acid and lactic acid accumulate and cause beriberi. In adults, approximately 1 mg of thiamine per day is completely degraded by the tissues, and this is roughly the minimal daily requirement. Thiamine is well absorbed from the gastrointestinal tract and is widely distributed to most body tissues. Excess beyond body requirements is excreted in the urine as unchanged drug or as metabolites.

In the treatment of mild chronic Thiamine deficiency doses up to 30 mg daily in single or divided doses have been recommended. In severe Thiamine deficiency doses up to 300 mg daily have been given.

Thiamine has no known severe interactions with other drugs.

Hypersensitivity to Thiamine.

No untoward effects occur when Thiamine is administered orally in amounts many times greater than the therapeutic dose.

The drug may be given safely to neonates, children, pregnant and lactating women, and elderly patients.

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Thiamine overdose does not cause toxicity.

Vitamin-B preparations

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.