This preparation is a combination of antitussive, decongestant, and antihistamine agents. Dextromethorphan is a safe, effective, non-narcotic antitussive agent that acts centrally on the cough center in the medulla. Although structurally related to morphine, it has no analgesic or habit-forming properties and generally causes little sedation. Phenylephrine is a decongestant that constricts blood vessels in the nasal passages. It is used to relieve nasal and sinus congestion, including congestion of the tubes that drain fluid from the inner ear. Triprolidine provides symptomatic relief in conditions that depend wholly or partly on histamine release. It is a potent competitive H1-receptor antagonist of the pyrrolidine class and has mild central nervous system depressant effects, which may cause drowsiness.

Adults & Children 12 years of age and older: 1 teaspoonful (5 ml) every 4 hours, or as directed by a doctor.

Children 6 to under 12 years of age: ½ teaspoonful (2.5 ml) every 4 hours, or as directed by a doctor.

Children 2 to 6 years: To be used with caution, and as advised by the physician for children aged 2 to 6 years.

Children below 2 years old:  Not to be used in children below 2 years old.

Take with or without food. Take with food if it causes an upset stomach. Measure liquid doses carefully. Use the measuring device that comes with this medicine.”

Concomitant use of this medicine with certain MAO inhibitors may cause serious or potentially fatal drug interactions. Drugs such as isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, and tranylcypromine should be avoided during treatment. Most MAO inhibitors should also not be used within two weeks before starting this medication. Caution is required when used with antihistamines applied to the skin (e.g. diphenhydramine cream/ointment/spray), antispasmodics (atropine, belladonna alkaloids), beta-blockers (metoprolol, atenolol), antiparkinson drugs (benztropine, trihexyphenidyl), guanethidine, certain inhaled anesthetics (halothane), methyldopa, reserpine, scopolamine, tricyclic antidepressants (amitriptyline, desipramine), antiepileptics (carbamazepine), sedatives or anxiolytics (alprazolam, diazepam, zolpidem), muscle relaxants, opioid analgesics (codeine), and psychiatric medicines (chlorpromazine, risperidone, amitriptyline, trazodone).

It should be avoided in patients with liver disease or asthma. It is contraindicated in patients receiving monoamine oxidase inhibitors or within 2 weeks of stopping such therapy. It is also contraindicated in patients with known hypersensitivity to phenylephrine hydrochloride or dextromethorphan hydrobromide, during acute asthma attacks, severe hypertension, or severe coronary artery disease.

May cause drowsiness, dizziness, and constipation. Other possible effects include gastrointestinal discomfort. There is no clear evidence of morphine-type dependence. Less common effects may include transient hypertension, dry mouth, restlessness, palpitations, allergic reactions such as rash, chest tightness, thickened bronchial secretions, toxic psychosis, and blood dyscrasia.

As with most drugs, use during pregnancy and lactation should be avoided unless clearly necessary.

This medicine may cause drowsiness; patients should not drive or operate machinery if affected. Alcohol should be avoided. Use with caution in epilepsy, prostate enlargement, glaucoma, liver disease, hypertension, heart disease, diabetes, hyperthyroidism, peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction unless under medical supervision. If symptoms do not improve within one week or are accompanied by high fever, consult a physician.

In case of overdose, hospital admission is strongly recommended. Symptoms may include respiratory depression, paranoid psychosis, hallucinations, delusions, and convulsions. Treatment includes gastric emptying via lavage or aspiration. Seizures may be treated with sedatives such as diazepam. Severe excitation may require diazepam or short-acting barbiturates.

Severe phenylephrine overdose may cause hypertension with reflex bradycardia. Management includes gastric lavage and supportive treatment. Hypertension may be treated with an alpha-blocker (e.g. phentolamine), and bradycardia with atropine after blood pressure control.

Combined cough suppressants.

Keep out of reach of children. Store in a cool and dry place. Protect from light.