Urea 10% cream is indicated for

• ichthyosis and other dry skin conditions,
• management of eczema
•  and management of psoriasis.

Topical urea has multiple actions including bacteriostatic, bactericidal, fungistatic, proteolytic, hygroscopic, and mild local anesthetic effects. These effects are dose dependent. Its main therapeutic benefit is due to its hygroscopic property, which increases water retention in the stratum corneum by altering protein configuration. A 10% urea cream has been shown to increase water-holding capacity of ichthyotic skin by up to 100% after 3 weeks of use. Percutaneous absorption data are limited, and its effects are mainly local rather than systemic. If absorbed, urea is excreted unchanged in urine.

Urea 10% cream is applied topically. Wash affected areas well, rinse off all traces of soap, dry and apply sparingly twice daily. Occlusive dressings may be used, but are usually unnecessary because of the self-occlusive nature of the cream..

Use in children: Urea 10% cream can be used in all age groups.

No clinically significant or hazardous drug interactions have been reported with topical Urea 10% cream.

Urea 10% cream is contraindicated in patients with known hypersensitivity to urea or any of the other ingredients in the formulation.

Topical urea is generally considered safe and no serious toxicity has been reported. However, in some cases it may cause burning sensation or irritation, especially when applied to inflamed, broken, or exudative skin.

Urea cream can be safely used during pregnancy and lactation.

Urea 10% cream may occasionally cause local irritation or mild edema when applied to sensitive skin. If symptoms worsen or no improvement is seen, medical advice should be taken. Avoid application on moist or broken skin.

Topical urea preparations

Keep out of reach of children. Do not freeze. Store in a cool and dry place.