Adults & children over 12 years: This preparation is intended for the symptomatic treatment of anhydrosis of the heels and feet, including in general consumers and diabetic patients.

Topical urea exhibits multiple actions including bacteriostatic, bactericidal, fungistatic, proteolytic, hygroscopic, and mild local anesthetic effects. These effects are dose dependent. Its main therapeutic benefit comes from its hygroscopic property, which induces structural changes in stratum corneum proteins. Urea helps dissolve the intercellular matrix, loosens the horny layer of the skin, and promotes regular shedding of scaly skin, thereby softening hyperkeratotic areas. Its therapeutic effect depends on local concentration rather than systemic absorption. If absorbed, urea is excreted unchanged in urine.

Apply enough Urea 25% Cream to cover affected area, once or twice daily or as directed by the physician. For external use only.

No clinically significant or hazardous drug interactions have been reported with this product.

This product is contraindicated in patients with known allergy or hypersensitivity to any of its ingredients.

Topical urea is generally considered safe and no serious toxicity has been reported. However, in some cases it may cause burning sensation or irritation, especially when applied to inflamed, broken, or exudative skin.

There are no adequate and well-controlled studies in pregnant women. Urea should be used only if the expected benefit outweighs the potential risk.

Avoid contact with eyes. Do not use if allergic to any ingredient. Avoid application on genital area or other sensitive skin areas, severely cracked, infected, or bleeding skin, and avoid simultaneous use with other skin care products. Discontinue use if irritation or rash occurs.

Topical urea preparations

Store in a cool and dry place, protected from light. Do not freeze.