Therapeutic purpose:

• Inflammatory conditions of the uveal tract.
• May be used in temporary lowering of intraocular pressure in glaucoma.

Diagnostic purpose:

• Retinal photography.
• Refractive errors.
• Fundus examination/photography.
• Slit lamp examination.

Pre-operative use: Used before surgical procedures requiring visualization of structures behind the iris, such as cataract extraction, vitrectomy, and retinal detachment surgery

Tropicamide blocks muscarinic receptors (M4) in the eye muscles. It inhibits the response of the iris sphincter and ciliary muscles to cholinergic stimulation, leading to pupil dilation (mydriasis) and paralysis of the ciliary muscle (cycloplegia).

Phenylephrine Hydrochloride is a selective alpha-1 agonist that causes mydriasis without cycloplegia. It reduces intraocular congestion through vasoconstriction.

Uveitis: 1-2 drops bid-qid or as required.

Diagnostic purpose/Pre-operative purpose: Instill 1-2 drops in the eye(s) 15-20 minutes before examination. If examination is not conducted within 20–30 minutes, an additional drop may be placed in the eye(s) to prolong the effect.

Tropicamide may interfere with the antihypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors.

This medication is contraindicated in the following cases:

• Patients with hypersensitivity to any component of the product and those with narrow angle or narrow angle glaucoma.
• Low birth weight infants and elderly patients with severe arteriosclerotic cardiovascular or cerebrovascular disease.
• During intraocular operative procedures when the corneal epithelial barrier is disturbed.

Elevated IOP (occasionally), stinging, blurred vision, tachycardia, photophobia, headache, parasympathetic stimulation, and allergic reactions. Systemic effects may include arrhythmias, hypertension, and coronary artery spasm.

The safety of this medication during pregnancy or lactation has not been established.

Caution should be taken when administered with, or up to 21 days after administration of monoamine oxidase (MAO) inhibitors, as exaggerated adrenergic effects may occur.

Psychotic reactions and behavioral disturbances should be considered in patients hypersensitive to anticholinergic drugs.

Use with extreme caution in infants.

Excessive use in children and certain susceptible individuals may produce systemic toxic symptoms.

Preparations for ophthalmic diagnosis

Keep out of the reach of children. Store in a cool, dry place away from heat and direct light. Do not use more than 4 weeks after opening.