This preparation is indicated for supportive nutritional supplementation in conditions requiring these vitamins. Such conditions include disorders causing depletion, reduced absorption, or decreased bioavailability of vitamins, including gastrointestinal diseases, chronic alcoholism, febrile illness, prolonged debilitating disorders, hyperthyroidism, poorly controlled diabetes, pregnancy, severe burns, and recovery after surgery. It is also used in the management of beriberi, peripheral neuritis, Wernicke’s encephalopathy, impaired carbohydrate metabolism due to thiamine deficiency, cheilosis, angular stomatitis, glossitis, keratitis, seborrhoeic dermatitis, photophobia, and corneal vascularization.

This preparation is a combination of three important vitamins from the vitamin B-complex group: Thiamine (Vit. B1), Riboflavin (Vit. B2), and Pyridoxine (Vit. B6). It is specially formulated for nutritional supplementation in conditions where these vitamins are required. B-complex vitamins are essential for converting carbohydrates, proteins, and fats into tissue and energy.

Thiamine (Vitamin B1) combines with adenosine triphosphate to form thiamine pyrophosphate, an essential coenzyme involved in carbohydrate metabolism.

Riboflavin (Vitamin B2) is necessary for energy utilization from food and is essential for normal tissue respiration. It is also involved in the activation of pyridoxine and the conversion of tryptophan into nicotinic acid.

Pyridoxine (Vitamin B6) is a water-soluble vitamin involved in the metabolism of carbohydrates, proteins, and fats. It plays an important role in hemoglobin formation and GABA synthesis within the central nervous system. It also assists in releasing glycogen stored in the liver and muscles.

Adults: 2 ml every day or alternate days intravenously or intramuscularly.

Pyridoxine may increase the peripheral metabolism of levodopa, thereby reducing its therapeutic effectiveness in patients with Parkinson’s disease.

This preparation is contraindicated in patients with hypersensitivity to any of its ingredients.

Adverse reactions have been reported with specific vitamins, generally at doses substantially higher than those contained in Vitamin B1, B2, and B6 preparations. However, allergic and idiosyncratic reactions may occur even at lower doses.

The recommended dose should not be exceeded unless advised by a physician.

This preparation should be administered cautiously in patients receiving levodopa therapy, as pyridoxine may reduce the effectiveness of levodopa. Hypersensitivity reactions may develop in patients previously treated with thiamine, especially following repeated injections of concentrated solutions. Subsequent injections should therefore be administered carefully. If adverse reactions occur, the medication should be discontinued. Intramuscular administration may cause temporary pain; when administered undiluted, it should be injected slowly.

Specific combined vitamin preparations, Vitamin-B preparations

Store below 25°C in a dry place, protected from light.