The active ingredients of Vitamin C and Vitamin E have been associated with a reduced risk of cardiovascular diseases in humans. Concurrent use of Vitamin E and Vitamin C suggests a synergistic effect between these two vitamins.

Vitamin C: Essential for collagen synthesis and tissue repair. It participates in oxidation-reduction reactions and various metabolic pathways including the synthesis of catecholamines, carnitine, and steroids. It also plays a role in the conversion of folic acid into folinic acid.

Vitamin E: Helps protect red blood cells from hemolysis and provides protective effects against free radical damage to polyunsaturated fatty acids present in cell membranes. It also contributes to preventing the oxidation of vitamins A and C.

Vitamin C & E capsule is administered orally. The adult dose is 1 capsule daily or as directed by the registered physician.

Vitamin C is incompatible in solution with aminophylline, bleomycin, erythromycin lactobionate, nafcillin, nitrofurantoin sodium, conjugated estrogens, sodium bicarbonate, sulphafurazole diethanolamine, chloramphenicol sodium succinate, chlorothiazide sodium, and hydrocortisone sodium succinate. It may increase the apparent half-life of paracetamol and enhance iron absorption from the gastrointestinal tract. No clinically significant beneficial drug interaction with Vitamin E has been established. However, high doses of Vitamin E may reduce intestinal absorption of Vitamins A and K.

High-dose Vitamin C is contraindicated in patients with hyperoxaluria. Pregnant women taking more than 5 g of ascorbate daily may be at risk of fetal abortion. Excessive doses of Vitamin C have also been reported to interfere with conception. For Vitamin E, there is no absolute contraindication.

Vitamin C is generally well tolerated. However, large doses may cause diarrhea and other gastrointestinal disturbances. Vitamin E is also usually well tolerated, although high doses may result in diarrhea, abdominal discomfort, other gastrointestinal disturbances, fatigue, and weakness.

Pregnancy Category A. Adequate and well-controlled studies in humans have not demonstrated any risk to the fetus during the first trimester, and there is no evidence of risk in later trimesters.

Vitamin C should be administered cautiously in patients with hyperoxaluria. In patients taking oral anticoagulants or estrogens, Vitamin E should be used carefully because it may antagonize the effect of Vitamin K, potentially increasing blood clotting time.

Anti-oxidant Multivitamin preparations, Specific combined vitamin preparations

Store below 30°C, protected from light and moisture. Keep out of the reach of children.