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Vitamin E [Alpha Tocopherol Acetate]

Generic Medicine
Indications

Vitamin E is indicated for the treatment and prevention of vitamin E deficiency. Vitamin E (d-alpha tocopherol) is also suggested to be used as an antioxidant to promote, prevent, and treat various health conditions such as:

  • Alzheimer's Disease
  • Rheumatoid Arthritis Pain
  • Nerve Damage caused by Chemotherapy
  • Male Infertility
  • Age-related Macular Degeneration
  • Keratectomy
  • Premenstrual Syndrome
  • Painful Menstrual Periods
  • Heart Disease (to improve effectiveness of nitrates), etc.
Pharmacology

Vitamin E acts as an antioxidant in the body. Vitamin E protects polyunsaturated fatty acids (which are components of cellular membranes) and other oxygen-sensitive substances such as vitamin A and vitamin C from oxidation. In premature neonates, irritability, edema, thrombosis, and hemolytic anemia may be caused due to vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival, or increased in vitro hemolysis by oxidizing agents have been identified in adults and children with low serum tocopherol concentrations.

Dosage Administration

Age-related Macular Degeneration: Vitamin E 400-600 IU daily.

Heart Disease (to improve effectiveness of Nitrates): Vitamin E 200 IU three times daily.

Dementia/Alzheimer’s Disease: Vitamin E 800-2000 IU one-two times daily.

Rheumatoid Arthritis Pain: Vitamin E 600 IU daily.

Improving Male Infertility: Vitamin E 200-600 IU daily.

Menstrual Syndrome: Vitamin E 400 IU daily.

Painful Menstrual Period: Vitamin E 200 IU daily.

Interactions

Vitamin E may impair the absorption of vitamin A and the function of vitamin K, and potentiates the effect of Warfarin.

Contraindications

Contraindicated in patients with known hypersensitivity to vitamin E. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltase insufficiency should not take this medicine.

Side Effects

Diarrhea and abdominal pain may occur with doses greater than 1000 IU daily.

Pregnancy & Lactation

There is no evidence of the safety of high doses of vitamin E in pregnancy; therefore, it should not be used in pregnancy, especially in the first trimester. No information is available on excretion in breast milk; therefore, it is advisable not to use it during lactation.

Precautions & Warnings

Vitamin E has been reported to increase bleeding tendency in vitamin K deficient patients or those taking anticoagulant treatments; it is therefore recommended to monitor the prothrombin time and international normalized ratio (INR) to detect any changes in hemostasis. Vitamin E has been reported to increase the risk of thrombosis in patients predisposed to this condition, including patients taking estrogens. This finding has not been confirmed but should be borne in mind when selecting patients for treatment, in particular women taking oral contraceptives containing estrogens.

Overdose Effects

Transient gastrointestinal disturbances have been reported with doses greater than 1000 IU daily, and where necessary, general supportive measures should be employed.

Therapeutic Class

Herbal and Nutraceuticals, Vitamin-E Preparations

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Common Questions

What is Vitamin E [Alpha Tocopherol Acetate] for?

What does Vitamin E [Alpha Tocopherol Acetate] do?

What are the side effects of Vitamin E [Alpha Tocopherol Acetate]?

What happens if you take too much Vitamin E [Alpha Tocopherol Acetate]?

Can Vitamin E [Alpha Tocopherol Acetate] be taken during pregnancy?

No available drugs found

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