Coenzyme Q10 is indicated in:
Infertility
Neurological disorders
Cardiovascular disease
Others
The USP refers to Coenzyme Q10 as Ubidecarenone, which is a fat-soluble, vitamin-like substance. It is present in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production. The highest requirement of Ubidecarenone is found in the cells and tissues that are metabolically active, such as the heart, immune system, skeletal muscle, and gingiva, and these are most susceptible to Ubidecarenone deficiency. The production of Ubidecarenone slows down with advancing age and thus contributes to the manifestation of aging.
As Ubidecarenone is a lipophilic substance, it is absorbed less on an empty stomach and absorbed in greater amounts when taken with food of high lipid content. Thus, after oral administration, Ubidecarenone is absorbed from the small intestine into the lymphatic system and then taken up by the liver, where it is incorporated into lipoproteins and released into the blood circulation, and at that time concentrated in the tissues.
Ubidecarenone is distributed to the various tissues of the body and is able to enter the brain. The concentration varies from tissue to tissue, and those with high rates of metabolic activity and high energy demands, such as the heart, muscle, liver, kidney, and brain, contain relatively high concentrations of Ubidecarenone. Ubidecarenone is metabolized in all tissues of the body. Approximately 60% of an oral dose of Ubidecarenone is excreted in the feces. The main elimination of Ubidecarenone occurs with bile.
For Co-enzyme Q10 deficiency: 150 mg daily.
For mitochondrial disorders: 150-160 mg, or 2 mg/kg/day.
For heart failure in adults: 100 mg per day divided into 2 or 3 doses.
For recent myocardial infarction: 120 mg daily in 2 divided doses.
For high blood pressure: 120-200 mg per day divided into 2 doses.
For isolated systolic hypertension: 60 mg twice daily.
For preventing migraine headache: 100 mg three times daily.
For Parkinson's disease: 300 mg, 600 mg, 1200 mg and 2400 mg per day in 3-4 divided doses.
For infertility in men: 200-300 mg per day.
For muscular dystrophy: 100 mg per day.
Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help to reduce side effects.
Statins: The statin drugs reduce endogenous synthesis of Ubidecarenone in the body. Thus, Ubidecarenone supplementation may increase Ubidecarenone levels without adversely affecting statin drug efficacy.
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta-blockers (particularly propranolol) have been reported to inhibit some Ubidecarenone-dependent enzymes.
Antidiabetic medications: May improve glycemic control in some type II diabetics. If this occurs, antidiabetic medications may need appropriate dose adjustment.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin.
Coenzyme Q10 is contraindicated in patients who have hypersensitivity to the active substance or to any of the excipients. It is also contraindicated in patients scheduled for surgery in the next two weeks.
Coenzyme Q10 is safe for most adults. It can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people.
Coenzyme Q10 should not be used during pregnancy and breastfeeding.
Coenzyme Q10 may lower blood sugar levels, so caution should be taken in patients with diabetes or hypoglycemia.Coenzyme Q10 may decrease blood pressure, so caution is advised in patients with low blood pressure or those taking blood pressure medications.
Herbal and Nutraceuticals, Supplements & adjuvant therapy
Keep in a dry place away from light and heat. Keep out of the reach of children.
What is Coenzyme Q10 (Ubidecarenone) for?
What does Coenzyme Q10 do?
What are the side effects of Coenzyme Q10?
What happens if you take too much Coenzyme Q10?
Can Coenzyme Q10 be taken during pregnancy?
No available drugs found