This preparation is indicated for the treatment and prevention of:

• Osteoarthritis
• Joint pain and inflammation
• Joint immobility and stiffness
• Rheumatoid arthritis
• Strenuous exercise and sports injury

Each tablet contains:

• Undenatured Collagen II USP 40 mg
• Glucosamine Sulfate 500 mg as Glucosamine Sulfate Potassium Chloride USP
• Chondroitin Sulfate 250 mg as Chondroitin Sulfate Sodium USP
• Methylsulfonylmethane USP 100 mg

Undenatured Collagen II is derived from chicken sternum cartilage and prevents the breakdown of bone joint cartilage by releasing collagen-specific T-regulatory cells. It also slows the production of inflammatory cytokines. The therapeutic potential of Undenatured Collagen II in joint disease depends on a specific dose of 40 mg. Glucosamine is the essential building block of joint cartilage that additionally reduces the synthesis of inflammatory and degenerative mediators responsible for the breakdown of cartilage. Chondroitin is a structural component of cartilage that maintains water and nutrients to promote elasticity and resistance in cartilage. It protects cartilage from premature decline by preventing the matrix metalloproteinase enzyme. Methylsulfonylmethane is necessary to maintain and repair healthy joints, tendons, ligaments, and connective tissues. It reduces the expression of cyclooxygenase-2 and nitric oxide by suppressing nuclear factor-kappa β, thus producing an analgesic and anti-inflammatory effect in reducing osteoarthritis pain and swelling. The combination of these four active ingredients gives a synergistic effect in osteoarthritis and improves joint function.

Orally, 1 tablet daily after a meal or as directed by the physician.

Caution should be practiced when administering this combination concomitantly with anticoagulants. Glucosamine Sulfate can alter the gastrointestinal absorption of Tetracycline, Penicillin, and Chloramphenicol. This combination can be used concomitantly with analgesics or anti-inflammatory drugs.

Contraindicated in patients with known hypersensitivity to Undenatured Collagen II, Glucosamine Sulfate, Chondroitin Sulfate, or Methylsulfonylmethane. Contraindicated for patients under 18 years of age, with phenylketonuria, and with severe renal insufficiency.

Generally well tolerated at the recommended dose. Occasionally, mild epigastric pain, constipation, diarrhea, bloating, and nausea may occur. Rarely, headache and visual disturbance may occur.

Not recommended during pregnancy and lactation.

Drugs for Osteoarthritis, Herbal and Nutraceuticals, Specific mineral & vitamin combined preparations

Do not store above 30°C. Protect from light and moisture. Keep out of reach of children.