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Silymarin [Dried extract of milk thistle fruits]

Generic Medicine
Indications

Silymarin (Milk Thistle) is indicated for the treatment and prevention of:

  • Liver disease (non-alcoholic & alcoholic)
  • Liver cirrhosis (non-alcoholic & alcoholic)
  • Infectious hepatitis
  • Drug-induced hepatitis
  • Liver disease secondary to diabetes mellitus
  • Toxicity caused by narcotics
  • Fatty liver
  • Jaundice
Composition

Each capsule contains a standardized extract of

  • Milk Thistle 175 mg equivalent to Silymarin 140 mg
  • Milk Thistle 87.50 mg equivalent to Silymarin 70 mg
Pharmacology

Silymarin is a well-known hepatoprotective agent. It is prepared from a standardized extract of Milk Thistle fruits.

Silymarin stimulates RNA polymerase-A, enhances protein synthesis, and helps in regeneration and repair of liver cells. The liver-protecting and liver-repairing effects of Silymarin are mainly due to its antioxidant and protein-restoring activities. Its antioxidant activity is about ten times more powerful than vitamin E.

It prevents toxic and foreign substances from entering liver cells by stabilizing the outer membrane of hepatocytes. Silymarin also has a membrane-stabilizing effect by altering liver cell structure in a way that prevents toxin entry. It protects liver cells from damage caused by alcohol, organic compounds, viral infections, acetaminophen, environmental pollutants, and metabolic by-products including foods, drugs, chemotherapeutic agents, and other chemicals.

It also acts through anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane-stabilizing, immunomodulatory, and liver-regenerating mechanisms.

Dosage Administration

Adults: 1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician.

Children: It should not be given to children without advice of physician.

Interactions

Concomitant use of Silymarin with butyrophenones or phenothiazines has been shown to reduce lipid peroxidation.

Contraindications

Contraindicated in patients with known hypersensitivity to Silymarin.

Side Effects

Generally well tolerated at recommended doses. Occasionally, a mild laxative effect may be observed.

Pregnancy & Lactation

There is no sufficient experience regarding the use of Silymarin 70 mg or 140 mg during pregnancy and lactation. Therefore, if necessary, it should be used with caution under a physician’s advice.

Therapeutic Class

Cholagogues, Cholelitholytics & Hepatic Protectors, Herbal and Nutraceuticals.

Storage Conditions

Store in a cool, dry place, protected from light and moisture. Keep out of the reach of children.

Common Questions

What is Silymarin [Dried extract of milk thistle fruits] for?

What does Silymarin [Dried extract of milk thistle fruits] do?

What are the side effects of Silymarin [Dried extract of milk thistle fruits]?

What happens if you take too much Silymarin [Dried extract of milk thistle fruits]?

Can Silymarin [Dried extract of milk thistle fruits] be taken during pregnancy?

No available drugs found

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