Chloramphenicol (Ophthalmic) is indicated for the treatment of ocular infections affecting the conjunctiva and/or cornea caused by organisms that are sensitive to chloramphenicol. These include bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, **Klebsiella / Enterobacter species, Moraxella lacunata, and **Neisseria species.

Chloramphenicol is a broad-spectrum bacteriostatic antibiotic. It works by inhibiting bacterial protein synthesis, specifically by interfering with the transfer of activated amino acids from soluble RNA to the bacterial ribosome.

Adult and Children: Instill 1 or 2 drops in the conjunctival sac 4-6 times per day for the first 72 hours and then every 4 hours thereafter. Treatment should be continued for approximately 7 days, but should not be continued for more than 3 weeks without re-evaluation by the physician.

Chloramphenicol may reduce or inhibit the activity of Chymotrypsin when both are administered at the same time.

Chloramphenicol should not be used in patients who have a known hypersensitivity or allergic reaction to chloramphenicol or to any component of this formulation.

With short-term topical use of Chloramphenicol, systemic adverse effects are generally uncommon. However, some patients may experience local reactions such as burning or stinging sensation, conjunctival redness (hyperemia), or allergic and inflammatory reactions. In rare cases, skin reactions like vesicular or maculopapular dermatitis and blood-related disorders (blood dyscrasias) have been reported.

The safety of Chloramphenicol during pregnancy and breastfeeding has not been fully established. Therefore, it should be used only when the physician considers it clearly necessary.

Chloramphenicol ophthalmic solution should not be used for minor eye infections or as a preventive treatment. Repeated courses and prolonged therapy should be avoided. Long-term use may increase the risk of blood dyscrasias, including granulocytopenia, thrombocytopenia, and moderate anemia.

Accidental swallowing of Chloramphenicol ophthalmic preparation is unlikely to cause significant toxicity because it contains only a small amount of the antibiotic.

Ear Anti-infectives & Antiseptics, Eye Anti-infectives & Antiseptics, Antibiotics (Broad-spectrum)

Store Chloramphenicol in a cool place (2°C–8°C) and keep it dry and protected from light. Keep the medicine out of the reach of children. Avoid touching the dropper tip to any surface to prevent contamination of the solution. Do not use the product more than 30 days after first opening.