Monosemicarbazone Adrenochrome is used for the prevention and treatment of capillary bleeding, both in surgical and non-surgical settings.

Adrenochrome Monosemicarbazone is a hemostatic (bleeding-control) agent with a rapid onset of action. It contains a water-soluble form of adrenochrome monosemicarbazone, a stable derivative of adrenochrome, as the active substance. Adrenochrome is an oxidation product of adrenaline. It works by decreasing capillary permeability, which reduces both normal and pathological (abnormal) bleeding time. It achieves capillary hemostasis without affecting respiration or the cardiovascular system. Therefore, despite having an adrenaline-like effect on small blood vessels, it does not produce the general systemic effects associated with sympathomimetic drugs (such as increased heart rate or blood pressure).

For prevention and treatment of capillary bleeding, the dose depends on the severity of the condition. Generally, 4–12 tablets are taken daily in divided doses, preferably one hour before meals. Before surgery, treatment should begin on the previous evening, either orally or by intramuscular or subcutaneous injection, usually at a dose of 1.5–5 mg. An additional injection is given about 30 minutes prior to the surgical procedure.

The injection solution should be administered via intramuscular or subcutaneous routes; in emergency situations, it may be given intravenously. Tablets are intended for oral use.

No specific drug interactions have been demonstrated with this medication.

There are no known contraindications for the use of this medication.

No adverse reactions have been reported when this medication is used at the recommended dosages.

During pregnancy, the benefits of using Monosemicarbazone Adrenochrome should be carefully weighed against the potential risks to the fetus.

Due to the presence of diprophylline (90 mg/mL) in the formulation, the dose of the 5 mg/mL injection for premature babies, infants, and young children should not exceed 0.3 mL.

Anti-fibrinolytic drugs

Store in a cool (between 2°C–25°C) and dry place. Protect from light. Keep out of the reach of children.