Uro-Vaxom is used as an immunotherapy for: Prevention of recurrent lower urinary tract infections (UTIs). Adjunct (co-medication) in the treatment of acute urinary tract infections.

Each capsule contains 6 mg of lyophilized bacterial lysate of Escherichia coli (derived from 18 pathogenic strains isolated from patients with recurrent UTIs). Other ingredients include: starch, magnesium stearate, propyl gallate (E310), sodium glutamate, mannitol, yellow iron oxide (E172), red iron oxide (E172), titanium dioxide (E171), and gelatin.

Uro-Vaxom is a biological immunostimulant that enhances the body’s natural defense mechanisms. It is used to prevent recurrent urinary tract infections, especially cystitis, and may be combined with other treatments such as antibiotics during acute infections.

It works by stimulating both innate and adaptive immune responses: After oral administration, it activates immune cells (phagocytes and antigen-presenting cells) through pattern recognition receptors (PRRs) in Peyer’s patches (GALT). These activated immune cells mature and migrate to the urinary tract, providing localized protection.

Innate immunity Increases cytokine production:

Enhances phagocytosis and adhesion molecules. Provides rapid immune defense Adaptive immunity: Stimulates lymphocyte activation. Increases IgA and IgG production. Provides long-term humoral immunity in the urinary tract.

By strengthening immune defenses and reducing inflammation in the bladder, Uro-Vaxom helps prevent recurrent UTIs and serves as a long-term alternative to conventional antimicrobial therapy.

Uro-Vaxom is indicated for use in adults and children from 4 years of age with dosing as follows

Preventive treatment: 1 capsule per day, preferably taken in the morning on an empty stomach, for 3 consecutive months (90 days).

Treatment of acute episodes: 1 capsule per day, preferably taken in the morning on an empty stomach as comedication to conventional antimicrobial therapy, until symptoms disappear, but for at least 10 consecutive days.

To data, the usage and safety of Uro-Vaxom have not been studied in children under 4 years old. Do not change the prescribed does on your own initiative. If you think that the effect of this medicine is too weak or too strong, talk to your doctor. The efficacy and safety of Uro-Vaxom have not been established in children below 4 years.

No drug interactions have been reported so far. Uro-Vaxom is not contraindicated with immunosuppressive drugs; however, such medications may reduce or inhibit its effectiveness.

Hypersensitivity to any component of Uro-Vaxom.

Common (up to 1 in 10 people): Diarrhea, nausea, headache, stomach discomfort, gastric intolerance.

Uncommon (up to 1 in 100 people): Allergic reactions, abdominal pain, skin rash, itching, fever.

Very rare (fewer than 1 in 10,000 people): Swelling (edema) of the mouth, ankles, feet, or fingers; hair loss.

Pregnancy: Use is not recommended, especially during the first trimester.

Breastfeeding: Should only be used after consulting a doctor.

Immunosuppressant