Difamilast ointment is used topically to treat atopic dermatitis, commonly known as eczema.

0.3% Ointment: Each gram of ointment contains Difamilast INN 3 mg.

1% Ointment: Each gram of ointment contains Difamilast INN 10 mg.

Difamilast is a phosphodiesterase 4 (PDE4) inhibitor. It works by increasing the concentration of cyclic adenosine 3',5'-monophosphate (cAMP) , which in turn suppresses the production of inflammatory cytokines. This mechanism exerts its therapeutic effect in the treatment of atopic dermatitis.

The usual adult dosage is an appropriate amount of the Difamilast 1% ointment applied to the affected area twice daily. The usual pediatric dosage is an appropriate amount of the Difamilast 0.3% ointment applied to the affected area twice daily.

Difamilast is contraindicated in individuals with a known hypersensitivity (allergic reaction) to the drug.

Well tolerated at the recommended dosage. At higher doses, it may cause mild skin reactions at the application site, such as redness, burning, or stinging.

Difamilast is not recommended for use in pregnant women or those who may become pregnant. The safety of this medicine during breastfeeding has not yet been fully established.

• For external use only. Difamilast ointment should not be used orally, in the eyes, or intravaginally.
• If any signs of hypersensitivity occur while using Difamilast, discontinue the treatment immediately.

Store below 30°C, protected from light and moisture. Keep out of reach of children.