This preparation is indicated for the treatment of:

• Acute hemorrhoidal attacks
• Chronic hemorrhoidal disease
• Organic and functional chronic venous insufficiency of the lower limbs, with the following symptoms:Heavy,legs,Pain,Nocturnal,cramps

Each film-coated tablet contains:

• Diosmin micronised BP: 450 mg
• Hesperidin micronised INN: 50 mg

Each DS film-coated tablet contains:

• Diosmin micronised BP: 900 mg
• Hesperidin micronised USP: 100 mg

Diosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Diosmin and Hesperidin decreases venous capacitance, venous distensibility, and venous emptying time.

Diosmin and Hesperidin protects the microcirculation by fighting the microcirculation damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Diosmin and Hesperidin normalizes capillary permeability and strengthens capillary resistance.

Diosmin and Hesperidin acts on the lymphatic system; it improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure

Diosmin 450 mg & Hesperidin 50 mg-

• Acute hemorrhoidal attacks: 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for three days, and if required, 1 tablet twice daily as a maintenance dosage.
• Chronic hemorrhoids: 1 tablet twice daily.
• Chronic venous insufficiency: 1 tablet twice daily initially for seven days. Duration may be increased depending on severity.

Diosmin 900 mg & Hesperidin 100 mg-

• Acute Hemorrhoid: 1 tablet thrice daily for the first 4 days, followed by 1 tablet twice daily for 3 days & then 1 tablet once daily as a maintenance dose.
• Relapse of Internal Hemorrhoid & Chronic Hemorrhoid: 1 tablet once daily for 3 months.
• Chronic venous insufficiency: 1 tablet once daily for 2–6 months.
• Leg Wounds: 1 tablet once daily for 2 months.

Tablet should be taken at meal times.

No evidence of drug incompatibility (drug interaction) has been reported in clinical trials.

Chronic venous insufficiency and its complications should be diagnosed and management monitored by a physician.It is contraindicated for anyone having a hypersensitivity to any ingredient in the product.

Some cases of routine gastric disorders and neurovegetative disorders (feeling of discomfort) have been reported.In such cases, discontinuation of treatment is not required.

 Experimental studies have not shown any teratogenic effect in animals. In human beings, no harmful effect has so far been reported.In the absence of data concerning excretion into breast milk, breastfeeding is not recommended during treatment.

If hemorrhoidal symptoms do not disappear within 15 days, the patient should seek medical advice. Diosmin (up to 900 mg/day) has been administered to a small number of breast cancer patients experiencing lymphedema following surgical and nodal irradiation treatment, with resultant reduction of arm edema but no effect on the cancer. Animal studies and more than 20 years of clinical use in Europe have not found any evidence of carcinogenicity or mutagenicity when the components of Diosmin & Hesperidin are used as recommended. As a precaution, Diosmin & Hesperidin is not recommended for patients with a history of cancer, since no specific studies have been performed in this population.

Phlebotonic & Vascular protecting preparation

Keep below 30°C.Protect from light and moisture.Keep out of the reach of children.