Acemetacin is used to -

• relieve pain and inflammation related to musculoskeletal and joint disorders, including rheumatoid arthritis, osteoarthritis, and lower back pain.
• It is also indicated for the management of pain following surgical procedures.

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting the cyclooxygenase (COX) enzyme, which is responsible for producing certain chemicals that trigger pain and inflammation in response to injury or rheumatic conditions. By blocking this enzyme, Acemetacin effectively reduces pain and inflammatory symptoms.

The recommended starting dose is 120mg/day in divided doses, increasing to 180mg/day in divided doses, depending on patient response. For the treatment of elderly patients, adjustment of dosage is not normally required. However, NSAIDs should be used with particular care in older patients who may be more prone to adverse reactions. Acemetacin should be taken with food, milk or an antacid to reduce the possibility of gastro-intestinal disturbance

Acemetacin may reduce the effectiveness of beta-blockers used for controlling blood pressure. When combined with quinolone antibiotics, it may increase the risk of seizures. Concomitant use with aspirin, other NSAIDs, or corticosteroids can raise the risk of gastrointestinal bleeding. Additionally, using Acemetacin with methotrexate may enhance methotrexate toxicity.

Acemetacin should not be used in patients with known hypersensitivity to Acemetacin or indomethacin, those suffering from peptic ulcer disease, and in children, as its safety in pediatric patients has not been established.

Common side effects of Acemetacin include loss of appetite, nausea, vomiting, diarrhea, constipation, peptic ulcer, headache, dizziness, and vertigo. In rare cases, patients may experience confusion, depression, swelling (edema), chest pain, or elevated blood urea levels.

The safety of Acemetacin during pregnancy and breastfeeding has not been clearly established. Animal studies have shown potential harmful and teratogenic effects on the fetus. Therefore, its use is not recommended during pregnancy and lactation.

Use Acemetacin with caution in elderly patients and in individuals with a history of gastrointestinal disorders, inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis, kidney or liver disease, and heart failure.

Non-steroidal Anti-inflammatory Drugs (NSAIDs).

Store Acemetacin in a cool, dry place below 25°C, protected from light.