Magnesium Oxide is indicated for the treatment of the following conditions:

• Relieving magnesium deficiency symptoms – Helps reduce symptoms caused by low magnesium levels in the blood.
• Heart and vascular system – For heart and blood vessel problems: rapid or irregular heartbeat, heart attack, angina pectoris, mild to severe hypertension.
• Nerves and muscles – For sudden or excessive muscle spasms (tetany), muscle cramps, stomach and intestinal cramps, increased excitability of muscles and nerves, calf cramps, and stress-related cramps in newborns or small children.
• Gynecological and birth-related conditions – Preterm spasms, cervical insufficiency, premature membrane rupture, spasms during pregnancy (eclampsia/pre-eclampsia, requiring betamimetic for tocolysis), painful menstruation.
• Orthopedic issues – Calcification and ossification of bones.
• Prevention of kidney stones – Prevents formation or recurrence of calcium oxalate kidney stones.
• Other conditions – Treatment of diabetes and migraine (a type of headache).

Magnesium is one of the most abundant minerals on earth and is present in many foods. Magnesium Oxide is a mineral supplement used to treat or prevent low magnesium levels in the blood. It is essential for human health and participates in over 600 cellular reactions throughout the body. Every cell and organ require magnesium to function properly. It contributes to bone health as well as proper brain, heart, and muscle function.

Magnesium prevents or controls convulsions by blocking neuromuscular transmission and reducing the release of acetylcholine at the neuromuscular junction. It has a depressant effect on the central nervous system but does not adversely affect the mother, fetus, or newborn when used as directed for eclampsia or pre-eclampsia.

Approximately 24–76% of ingested magnesium is absorbed in the gastrointestinal tract, primarily via passive paracellular absorption in the small intestine. About 20% of magnesium in human serum is protein-bound, with 60–70% bound to albumin and the remainder to globulin proteins. Magnesium can bind to over 3,700 human proteins and is largely excreted via the kidneys. Magnesium does not appear to be metabolized.

Recommended daily dose for patient over 12 years of age is 1-2 tablet. If a dose of Magnesium Oxide is missed take it as soon as remember, unless it's almost time for the next dose. In that case, skip the missed dose and continue on regular medication schedule. Do not double up on doses to make up for a missed dose.

Kidney failure: Do not take this medication in the patient with severe kidney failure.

Liver failure: There is no data about usage in the patients with liver failure.

Other drugs may affect the effectiveness of this medicine. Before taking Magnesium Oxide, consult your doctor if you are using:

• Muscle relaxant drugs (non-depolarizing neuromuscular blockers)
• Certain antibiotics (amino quinolones, nitrofurantoin, penicillamine, tetracyclines, fluoroquinolones)
• Digoxin (used for heart failure)
• Lithium (for mood changes and depression control)
• Sodium polystyrene sulfonate (helps eliminate potassium)
• Cellulose sodium phosphate (used to prevent kidney stones)
• Other magnesium-containing medicines (including magnesium enemas)
• Barbiturates (for insomnia), opioids (morphine-like drugs), hypnotics (sleep-inducing drugs)
• Nifedipine (used in hypertension or heart problems)
• The absorption of levothyroxine-containing drugs used for thyroid disease may be reduced when taken together with Magnesium Oxide. Therefore, maintain at least a 4-hour interval between these medicines.

• Do not take this drug without consulting your doctor if you have kidney disease.
• Before taking this drug, inform your doctor about any medical conditions, allergies, or other medications or herbal/health supplements you are taking. This medicine may not be recommended in certain situations.
• It is not known whether this drug can harm an unborn baby.
• Do not take this drug without consulting your doctor if you are pregnant or planning a pregnancy.
• It is not known whether this drug can harm a nursing baby.
• Do not take this drug without consulting your doctor if you are breastfeeding.

Common side effects: Diarrhea, Cramping.

Serious side effects: Itching, Rash or hives, Mood or mental changes, Lightheadedness or dizziness, Weakness, Unusual fatigue, Nausea, Vomiting. Consult your doctor immediately if any serious side effects occur.

Do not use this medicine during pregnancy without consulting your doctor. Do not use this medicine while breastfeeding without consulting your doctor.

• Do not take more magnesium than recommended by your doctor or as indicated on the product label. Excess magnesium in the blood may cause serious side effects.
• Before taking Magnesium Oxide, consult your doctor if you are allergic to it, or to antacids, laxatives, or any other medications.
• Do not use this supplement as an antacid for more than two weeks, or as a laxative for more than one week, unless advised by your doctor.
• Inform your physician if you have, or have ever had, liver, kidney, heart, or intestinal disease.
• Also inform your healthcare provider if you have, or have ever had, high blood pressure, or if you are on any special diet.
• Take other medications at least two hours before or two hours after taking Magnesium Oxide.

Antacids, Electrolyte preparations, Oral electrolyte preparations

Store below 25°C, protected from light and moisture. Keep all medicines out of the reach of children.