Aluminium Chloride Hexahydrate topical solution is indicated for the management of hyperhidrosis affecting the underarms (axillae), palms, and soles.

Aluminium Chloride Hexahydrate exerts its effect locally within the stratum corneum and the terminal portion of the sweat ducts to control excessive sweating. Aluminium salts lead to blockage of the sweat gland ducts at the skin surface. It is believed that aluminium ions interact with mucopolysaccharides, resulting in damage to epithelial cells lining the duct and forming a gel-like plug that obstructs sweat secretion.

This topical solution is for application to the axillae, palms of the hands or soles of the feet. Before applying Aluminium Chloride Hexahydrate, the affected area should be dried thoroughly to avoid burning of the skin. Apply this topical solution at night after drying the affected areas carefully. Wash off in the morning. Do not re-apply the product during the day. Initially the product may be applied each night until sweating stops during the day. The frequency of application may then be reduced to twice a week or less.

No known drug interactions have been reported with Aluminium Chloride Hexahydrate topical solution.

Contraindicated in individuals with hypersensitivity to the active ingredient or any of the formulation components.

Aluminium Chloride Hexahydrate may cause local skin irritation, which can be reduced by using a mild corticosteroid cream.

• Skin and Subcutaneous Tissue Disorders:
  Very common: Application site irritation
• Immune System Disorders:
  Not known: Hypersensitivity reactions at the application site, including dermatitis
• Skin and Subcutaneous Tissue Disorders:
  Not known: Local reactions such as pain, itching (pruritus), redness (erythema), rash, and burning sensation

Pregnancy: There are no adequate data regarding the use of topical Aluminium Chloride Hexahydrate in pregnant women. Animal studies have indicated reproductive toxicity when administered orally or parenterally. However, due to minimal skin absorption, adverse effects during pregnancy are not expected.

Lactation: It is not known whether this topical preparation is excreted into human milk. Due to limited systemic absorption, effects on the breastfed infant are unlikely. If used during breastfeeding, avoid application on the breast area. If accidental contact occurs, the area should be thoroughly washed before feeding.

Aluminium Chloride Hexahydrate reacts with water to form hydrochloric acid; therefore, the skin must be completely dry before application to prevent irritation or burning. Apply only to the affected areas. Avoid use on recently shaved (within 12 hours), broken, or irritated skin. Hair removal products should not be used on treated areas within 12 hours before or after application. Avoid contact with eyes, nose, mouth, and other mucous membranes. In case of accidental contact, rinse thoroughly with water. Prevent contact with clothing, jewelry, and polished metal surfaces.

Applying the product more frequently than recommended may increase the risk of skin irritation. Accidental ingestion may result in nausea, vomiting, diarrhea, and a burning sensation in the mouth and throat. Systemic absorption should be considered in cases of excessive exposure.

Miscellaneous topical agents.

Store in a cool, dry place, protected from light. Keep below 25°C. Keep away from open flames and store in an upright position.