Amino acid infusion is used as a source of amino acids for protein synthesis in patients who require intravenous nutrition. It is especially suitable for individuals with normal amino acid requirements. Additionally, it is beneficial in promoting faster recovery after surgery, burns, renal failure, hepatic impairment, and in supportive care for cancer patients.

Each 100 ml solution (5%) contains:

Essential Amino Acids:

• L-Isoleucine: 0.352 g
• L-Leucine: 0.490 g
• L-Lysine Hydrochloride: 0.430 g
• L-Methionine: 0.225 g
• L-Phenylalanine: 0.533 g
• L-Threonine: 0.250 g
• L-Tryptophan: 0.090 g
• L-Valine: 0.360 g
• L-Histidine: 0.250 g
• L-Tyrosine: 0.025 g

Non-Essential Amino Acids:

• L-Arginine: 0.500 g
• L-Aspartic Acid: 0.250 g
• L-Glutamic Acid: 0.075 g
• L-Alanine: 0.200 g
• L-Cystine: 0.010 g
• Glycine (Aminoacetic Acid): 0.760 g
• L-Proline: 0.100 g
• L-Serine: 0.100 g

Excipients:

• D-Sorbitol: 5.000 g

Electrolytes:

• Sodium (Na⁺): 57 mmol/L
• Potassium (K⁺): 25 mmol/L
• Magnesium (Mg²⁺): 1.2 mmol/L
• Chloride (Cl⁻): 87 mmol/L
• Acetate (CH₃COO⁻): 25 mmol/L

Additional Information:

• Total Nitrogen Content: 7.25 g/L
• Total Energy: 1551 kJ/L (371.14 kcal/L)

This intravenous solution provides a balanced combination of essential and non-essential amino acids along with D-sorbitol and electrolytes, making it suitable for parenteral nutrition. It supplies nitrogen necessary for protein synthesis and helps maintain a positive nitrogen balance, especially during postoperative recovery or prolonged intravenous feeding. The presence of multiple amino acids supports metabolic functions and tissue repair. The solution is clear, colorless to slightly yellow, with a pH range of approximately 5.0 to 7.0.

The nitrogen requirement for maintenance of body protein mass depends on the patient's condition (nutritional state and degree of metabolic stress).

• No or minor metabolic stress and normal nutritional state: 0.10–0.15 g nitrogen/kg/day,
• Moderate metabolic stress with or without malnutrition: 0.15–0.20 g nitrogen/kg/day,
• Severe catabolism in burns, sepsis and trauma: up to 0.20–0.25 g nitrogen/kg/day.

The dosage range 0.10–0.25 g nitrogen/kg/day corresponds to 15–35 ml Amino acids IV/kg/day.

In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000–2000 ml Amino acids IV may be infused intravenously per 24 hours. Amino acids IV should be infused slowly, at rates 1.4–2.8 ml (30–60 drops) per minute.

In children and infants: The rate of infusion is 28–35 ml/kg body weight per day is recommended, with a step-wise increase in the rate of administration during the first week.

Amino acid preparations are not known to have direct pharmacological effects and are generally not expected to interact with other medications.

This preparation is contraindicated in patients with inherited disorders of amino acid metabolism, severe liver impairment, and severe uremia where dialysis is not available.

Store at a temperature between 15°C and 25°C. Do not freeze. Keep out of the reach of children.