DHEA has been found to improve fertility in women with advanced ovarian age by increasing the number of eggs and embryos. DHEA tablets may serve as a beneficial nutritional supplement for individuals looking to support the body’s natural DHEA levels and functions.

DHEA may also play a role in supporting overall health in conditions such as heart disease, stress, cancer, immune deficiency, cognitive decline (including memory loss and Alzheimer’s disease), obesity, aging, inflammation balance, hormonal balance, mood regulation, bone health (including osteoporosis), cardiovascular disease, diabetes, depression, erectile dysfunction, adrenal insufficiency, systemic lupus erythematosus (SLE), and allergic disorders.

DHEA (dehydroepiandrosterone) is the most abundant steroid hormone produced by the adrenal glands in the human body. After being synthesized, it travels into cells where it is converted into androgens, estrogens, and other hormones. These hormones help regulate fat and mineral metabolism, endocrine and reproductive functions, as well as overall energy levels. The specific hormones produced from DHEA vary depending on an individual’s biochemistry, age, and sex. DHEA levels typically peak around the age of 25 and gradually decline with age. It is naturally produced in the body by the adrenal glands, liver, and small amounts in the brain; in men, it is also produced in the testes. DHEA is converted into androstenedione, a key precursor to both estrogens and androgens, thereby influencing the balance of these circulating hormones. In women, DHEA supplementation tends to significantly increase androgen levels, with a smaller effect on estrogen levels. In men, supplementation generally leads to a notable increase in estrogen levels, along with a more modest rise in androgens. These hormonal effects may contribute to the potential benefits associated with DHEA. Within the brain, DHEA is concentrated in the limbic regions and may function as an excitatory neuroregulator, opposing GABA activity. Additionally, DHEA supplementation may help reduce thromboxane A2 synthesis in platelets and increase levels of IGF-1, cGMP, and nitric oxide, which could support cardiovascular health.

Adrenal insufficiency: 50 mg/day for 3 months is considered a replacement dose, while 200 mg/day achieves supraphysiological circulating levels and is considered a pharmacological dose.

Anorexia nervosa: 100 mg/day for 6 months was used in a pilot study.

Diminished ovarian reserve: 50 to 75 mg/day (in divided doses) has been used in clinical studies of assisted reproduction.

Exercise training–induced muscle damage: 100 mg/day of Dehydroepiandrosterone supplementation was administered over 5 days in a study in young men undergoing exercise training.

Major depressive disorder: Doses ranging from 30 to 450 mg/day for 6 to 8 weeks have been used in clinical studies.

Metabolic syndrome: 100 mg/day for 3 months has been used in a study evaluating effects against metabolic syndrome in pre-and postmenopausal women.

Postmenopausal women: 25 mg/day has been suggested because this dose minimizes androgenic adverse effects; however, only studies in which at least 50 mg/day was used demonstrated positive outcomes as hormonal replacement therapy.

Use in children & adolescents: Not for use by individuals under the age of 18 years.

With medications:Calcium channel blockers: These may raise DHEA levels in some individuals; therefore, DHEA supplements should only be used together under close medical supervision.

• Glucocorticoids: Can suppress the body’s natural (endogenous) production of DHEA.
• Insulin: May reduce endogenous DHEA-S levels.
• Triazolam: DHEA may increase the blood (plasma) concentration of triazolam.
• Drugs metabolized via CYP3A: DHEA may inhibit the CYP3A enzyme and affect drug metabolism.

With food & other conditions:

• Diabetes: DHEA may improve insulin sensitivity.
• Hormone-sensitive cancers: DHEA may have estrogen-like effects.
• Liver dysfunction: DHEA may worsen liver function.

DHEA should not be used in individuals with a history of psychiatric disorders, including mania and bipolar disorder, as it may increase the risk of manic episodes. It is also contraindicated in patients with hormone-sensitive cancers because of its estrogen-like effects.

Common: Possible side effects may include acne, hair loss, increased facial hair growth in women, aggressiveness, irritability, and elevated estrogen levels.

Rare: Stop using immediately and consult a physician or qualified healthcare professional if you experience symptoms such as rapid heartbeat, dizziness, blurred vision, or similar effects.

Not recommended for use during pregnancy and breastfeeding.

• Consult a physician or qualified healthcare professional before using this product if you have, or a family history of, breast cancer, prostate cancer, enlarged prostate, heart disease, or low “good” cholesterol (HDL), or if you are taking any dietary supplements, prescription medications, or over-the-counter drugs.
• Individuals with hypertension should avoid using this product.
• Individuals with thyroid disorders, or those taking thyroid hormone therapy, may require medical monitoring.
• Do not exceed the recommended dose, as doing so may lead to serious adverse health effects.

Store the product at a temperature below 30°C in a cool, dry place, and protect it from light and moisture. Always keep it out of the reach of children to ensure safety.