This is intended as a supplement for intravenous nutrition to meet the daily requirements of water-soluble vitamins in dehydrated patients.

Each vial contains:

• Vitamin B1 (as Thiamine Nitrate): 2.5 mg
• Vitamin B2 (as Riboflavin Sodium Phosphate): 3.6 mg
• Nicotinamide: 40 mg
• Vitamin B6 (as Pyridoxine Hydrochloride): 4 mg
• Pantothenic Acid (as Dexpanthenol): 15 mg
• Ascorbic Acid (as Sodium Ascorbate): 100 mg
• Biotin: 0.06 mg
• Folic Acid: 0.4 mg
• Vitamin B12 (as Cyanocobalamin): 0.005 mg

This is a sterile, lyophilized powder of water-soluble vitamins for infusion. It contains a balanced amount of essential water-soluble vitamins that act as coenzymes in vital enzymatic reactions involved in physiological processes, energy metabolism, and cell growth and repair, especially in brain and nerve tissues. Vitamin C acts as an antioxidant and supports collagen synthesis. Intravenous administration provides rapid therapeutic action.

Adults and children weighing 10 kg or more: 1 vial (10 ml) daily.
Children weighing less than 10 kg: should be given 1 ml of the dissolved mixture per kg body weight/day.

The contents of one vial are dissolved by the aseptic addition of 10 ml of one of the following:

• Water for injection
• Fat emulsion 10%
• Glucose solution for infusion (5% to 60%)
• Normal saline (0.9% Sodium Chloride)

This IV preparation may be added to parenteral nutrition admixtures containing carbohydrates, lipids, amino acids, electrolytes, and trace elements provided that compatibility and stability have been confirmed.

Vitamin B6 may reduce the effect of levodopa. Folic acid may decrease the serum concentration of phenytoin.

Known hypersensitivity to any component of the preparation, e.g. thiamine.

Allergic reactions may occur in patients hypersensitive to any component of the preparation, e.g. thiamine.

Animal reproduction studies or clinical investigations during pregnancy have not been conducted with this preparation. However, published reports indicate that water-soluble vitamins can be safely administered in this patient group.

When lyophilized powder for infusion is diluted with water-based solutions, the admixture should be protected from light. This is not necessary when diluted with intralipid, as the fat emulsion provides a protective effect.

No adverse effects of overdose of water-soluble multivitamins have been reported, except in cases of extremely high parenteral doses. The possibility of hypervitaminosis A and D should be considered if the preparation is dissolved in another multivitamin injection.

Multivitamin & multimineral combined preparations

Before reconstitution: Store below 25°C in a dry place, protected from light. Keep out of reach of children. After reconstitution: Add aseptically to infusion solution immediately before infusion and use within 24 hours.