This combination is intended as a supplement for intravenous nutrition to fulfill the daily requirement of water-soluble vitamins in NPO and surgical patients.

Each vial contains:

• Vitamin B1 (as Thiamine Nitrate): 2.5 mg
• Vitamin B2 (as Riboflavin Sodium Phosphate): 3.6 mg
• Nicotinamide: 40 mg
• Vitamin B6 (as Pyridoxine Hydrochloride): 4 mg
• Pantothenic Acid (as Dexpanthenol): 15 mg
• Ascorbic Acid (as Sodium Ascorbate): 100 mg
• Biotin: 0.06 mg
• Folic Acid: 0.4 mg
• Vitamin B12 (as Cyanocobalamin): 0.005 mg

This is a sterile, lyophilized powder of water-soluble vitamins for intravenous infusion. It provides a balanced combination of essential vitamins that function as coenzymes in metabolic processes involved in energy production, tissue repair, and normal cellular function, particularly in brain and nerve tissues. Vitamin C also acts as an antioxidant and supports collagen formation. Intravenous administration ensures rapid onset of action.

Adults and children weighing 10 kg or more: 1 vial (10 ml) daily.

Children weighing less than 10 kg: should be given 1 ml of the dissolved mixture per kg body weight/day.

The contents of one vial are dissolved by the aseptic addition of 10 ml of one of the following:

• Water for injection
• Fat emulsion 10% (Fatisol)
• Glucose solution for infusion (5% to 60%)
• Normal saline (0.9% Sodium Chloride)

This IV preparation may be added to parenteral nutrition admixtures containing carbohydrates, lipids, amino acids, electrolytes and trace elements provided that compatibility and stability have been confirmed.

Vitamin B6 may reduce the therapeutic effect of levodopa. Folic acid may decrease the serum concentration of phenytoin.

Contraindicated in patients with known hypersensitivity to any component, such as thiamine.

Allergic reactions may occur in patients sensitive to any component of the preparation, such as thiamine.

Animal studies or clinical studies in pregnancy have not been conducted for this preparation. However, published data suggest that water-soluble vitamins are generally safe in this patient group when clinically indicated.

When lyophilized powder for infusion is diluted with aqueous solutions, the admixture should be protected from light. This is not necessary when diluted with fat emulsion due to its protective effect.

No adverse effects have been reported with overdose of water-soluble multivitamins, except in cases of extremely high parenteral doses. The possibility of hypervitaminosis A and D should be considered if combined with other multivitamin preparations.

Specific combined vitamin preparations

Before reconstitution: Store below 25°C in a dry place, protected from light. Keep out of reach of children. After reconstitution: The solution should be added aseptically to the infusion fluid immediately before administration and used within 24 hours.