Naftifine cream is an allylamine antifungal indicated for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum.

Naftifine is a synthetic broad-spectrum antifungal agent belonging to the allylamine class. In vitro studies demonstrate activity against various dermatophytes including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, Microsporum canis, Microsporum audouini, and Microsporum gypseum. It also shows fungistatic activity against Candida species such as Candida albicans. Clinically, it is used primarily for the infections mentioned in the indications.

Naftifine Hydrochloride is thought to inhibit the fungal enzyme squalene 2,3-epoxidase, disrupting ergosterol biosynthesis. This results in depletion of ergosterol and accumulation of squalene in fungal cells, leading to impaired cell membrane function and inhibition of fungal growth.

Apply a thin layer of Naftifine Hydrochloride Cream once-daily to the affected areas plus half inch margin of healthy surrounding skin for 2 weeks or as directed by the physician.

Use in Children and Adolescents: The safety and effectiveness of Naftifine Hydrochloride have been established in the age group of 12-17 years with interdigital tinea pedis and tinea cruris.

No information is available regarding drug interactions with Naftifine cream.

The most common adverse reaction (≥1%) is pruritus (itching).

Pregnancy Category B. Adequate and well-controlled studies in pregnant women are not available. Animal studies do not always predict human response. Therefore, Naftifine cream should be used during pregnancy only if clearly needed and if the potential benefit outweighs the risk to the fetus. It is not known whether the drug is excreted in human milk, so caution is advised during breastfeeding.

If irritation or hypersensitivity develops during use, treatment should be discontinued.

Topical overdose of Naftifine is not expected to cause serious harm.

Topical antifungal preparation

Store below 30°C in a dry place, protected from light. Keep out of reach of children.