Bismuth Subsalicylate is indicated for:

• Upset stomach
• Indigestion
• Heartburn
• Nausea
• Diarrhea

Antacid action: Bismuth Subsalicylate forms a protective coating over ulcer surfaces, shielding them from acid and pepsin. It enhances the secretion of mucus and bicarbonate and reacts with hydrochloric acid (HCl) to form bismuth oxychloride and salicylic acid, thereby reducing gastric acidity.

Anti-diarrheal action: It promotes absorption of water and electrolytes through the intestinal wall. In cases of infectious diarrhea, it binds to toxins produced by E. coli, disrupts bacterial cells, causes lysis of H. pylori, and prevents its adherence to the intestinal lining.

Anti-inflammatory action: After hydrolysis to salicylic acid, it inhibits prostaglandin G/H synthase, reducing inflammation and forming a protective layer over irritated tissues, which helps slow fluid loss.

Adult (>16): 30 ml in dosing cup provided or 6x5 ml spoonful
Children (10-14 years): 15 mL (3 teaspoons)
Children (5-9 years): 7.5 mL (1.5 teaspoons)
Children (3-4 years): 5 mL (1 teaspoon)
Children under 3 years: Ask a doctor.
Use in the elderly: No special precaution is needed.
Patient is suffering from renal insufficiency: caution should be taken.

Repeat dose every ½ to 1 hour if needed. Not more than 8 doses to be taken in 24 hours.

Bismuth Subsalicylate contains salicylates; therefore, caution is required when it is used alongside anticoagulants, oral antidiabetic medications, or drugs used for gout and arthritis.

Bismuth Subsalicylate should not be used in patients who are hypersensitive to aspirin, other salicylates, or any component of the formulation. All medicines should be kept out of the reach and sight of children.

Common effects include black discoloration of stool and tongue. Do not use this medicine if symptoms are severe or persist for more than two days. Avoid exceeding the recommended dose and shake the bottle well before use. For oral use only.

There is insufficient data regarding the use of Bismuth Subsalicylate in pregnant women. Animal studies are also inadequate to determine its effects on pregnancy, fetal development, delivery, and postnatal growth. The potential risk in humans is unknown. It should be avoided during breastfeeding unless clearly necessary.

Avoid using this medicine with aspirin or other salicylates. Patients taking anticoagulants, antidiabetic drugs, or medications for gout should use it with caution.

Bismuth toxicity may present as acute encephalopathy with confusion, involuntary muscle movements, tremor, speech difficulties, and problems with walking or balance. It may also cause gastrointestinal disturbances, skin reactions, discoloration of mucous membranes, and kidney dysfunction due to acute tubular necrosis. Management includes gastric lavage, purgation, and adequate hydration. Chelating agents may be helpful in early stages, and hemodialysis may be required in severe cases. Overdose may also produce symptoms of salicylate toxicity such as dizziness, tinnitus, sweating, nausea, and headache. If such symptoms occur, the medication should be discontinued. Management is similar to that of salicylate overdose.

Store below 30°C, protected from light and moisture. Keep out of reach of children.