Desloratadine is used to relieve symptoms of seasonal and year-round allergic rhinitis, including sneezing, runny nose, nasal itching, congestion, itchy or watery eyes, redness, itching of the palate, and coughing. It is also indicated for the treatment of chronic idiopathic urticaria, helping to reduce itching as well as the size and number of hives.

Desloratadine, the primary active metabolite of Loratadine, is a long-acting, non-sedating tricyclic antihistamine with selective H1-receptor antagonist activity. It also helps inhibit the release of histamine from human mast cells.

Pediatric drops:

• Child 6-11 months of age: 2 ml drops once daily.
• Child 1-2 years of age: 2.5 ml drops once daily.

Syrup:

• Child 6-11 months of age: 2 ml once daily.
• Child 1-5 years of age: 2.5 ml once daily.
• Child 6-11 years of age: 5 ml once daily.
• Adults & >12 years of age: 10 ml once daily.

Tablet: Adults and children 12 years of age and over: 1 tablet daily

No clinically significant drug interactions have been identified.

Desloratadine is contraindicated in patients with known hypersensitivity to this medication, any of its components, or to Loratadine.

Less common adverse effects may include headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia, and myalgia.

Pregnancy Category C. The safety of Desloratadine during pregnancy has not been established; therefore, it should be used during pregnancy only if clearly indicated. Desloratadine is excreted in breast milk, so a decision should be made to either discontinue nursing or discontinue the medication, considering the importance of treatment to the mother.

In adult patients with hepatic or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data. Caution is advised in patients with a personal or family history of seizures.

Recommended for use in children and adolescents.

No clinically significant adverse effects have been reported.

Non-sedating antihistamines

Store in a cool, dry place protected from light. Do not store above 30°C. Keep all medicines out of the reach of children.