This combination capsule is indicated for the treatment of patients with deficiencies of, or increased requirements for, vitamin B-complex and vitamin C. Conditions and patient groups include:

• Reduced intake due to restricted or unbalanced diets associated with anorexia, diabetes mellitus, obesity, and alcoholism
• Decreased vitamin availability during treatment with antimicrobials that alter normal intestinal flora, prolonged diarrhea, and chronic gastrointestinal disorders
• Increased nutritional requirements due to elevated metabolic activity in fever and tissue wasting conditions such as febrile illness, acute or chronic infections, surgery, burns, and fractures
• Stomatitis, glossitis, cheilosis, paraesthesias, neuralgia, and dermatitis
• Micronutrient deficiencies during pregnancy or lactation
• Use medicines according to the advice of a registered physician.

Each capsule contains:

• Ascorbic Acid BP 175.0 mg
• Calcium D-Pantothenate BP 25.0 mg
• Cyanocobalamin BP 5 mcg
• Folic Acid BP 500 mcg
• Thiamine Mononitrate USP 50.0 mg
• Riboflavin BP 25.0 mg
• Pyridoxine Hydrochloride BP 10.0 mg
• Nicotinamide BP 100.0 mg

Vitamin B-Complex and Vitamin C act as cofactors for multiple enzymes involved in the metabolism of carbohydrates, proteins, and fats.

Thiamine (B1) functions as a cofactor in the decarboxylation of keto acids such as pyruvic acid.

Riboflavin (B2) plays an essential role in cellular respiration processes together with nicotinamide.

Pyridoxine (B6) participates in the decarboxylation and interconversion of amino acids. It is also necessary for normal antibody-mediated and cell-mediated immune responses.

Vitamin B12 (cyanocobalamin) is essential for DNA (deoxyribonucleic acid) synthesis and for the maturation of red blood cells (RBCs).

Nicotinamide contributes significantly to cellular respiration in association with riboflavin.

Calcium Pantothenate acts as a cofactor for enzymes involved in acetyl group transfer. It is also required for normal antibody response in combination with pyridoxine.

Folic acid, after conversion to folinic acid within the body, participates in reactions associated with nucleotide synthesis and RBC maturation together with vitamin B12. It also plays an important role in lymphocyte-mediated immune responses.

Ascorbic acid (Vitamin C) is involved in biochemical oxidation reactions, collagen formation, and the conversion of folic acid into folinic acid. It is also required for normal phagocytic activity of white blood cells (WBCs).

An adequate supply of these water-soluble vitamins is essential for the optimal function of various cells and tissues. Except for vitamin B12, these vitamins are not stored in the body in significant amounts, and excess quantities are excreted through urine. Therefore, regular and sufficient intake is necessary to fulfill metabolic demands. Deficiencies of water-soluble vitamins frequently coexist because of overlapping dietary sources and metabolic interdependence. Initially, these deficiencies may remain subclinical and can only be detected through biochemical investigations. If left untreated, they may progress to symptoms such as poor wound healing and increased susceptibility to infections. Classical deficiency diseases such as beriberi, pellagra, and scurvy are uncommon, whereas mild and subclinical deficiencies are comparatively more prevalent, even among apparently healthy individuals.

One capsule daily or as advised by the physician.

Folic acid may reduce the serum concentration of phenytoin. Pyridoxine may decrease the therapeutic effectiveness of levodopa.

This preparation is contraindicated in patients with hypersensitivity to any of its ingredients.

Allergic reactions may occur in patients sensitive to any component of the preparation, such as methyl parahydroxybenzoate or thiamine. Rare cases of anaphylactoid reactions have been reported following repeated injections of preparations containing thiamine. Flushing, itching, or burning sensations of the skin may occur in individuals sensitive to nicotinamide.

Animal reproduction studies and adequate clinical investigations have not been performed with this preparation during pregnancy. However, published reports indicate that water-soluble vitamins can be administered safely in this patient population.

Patients with vitamin B-complex and vitamin C deficiency, or increased nutritional requirements, should receive appropriate treatment for the underlying disease along with supplementation. Therapy with this capsule should continue only until the deficiency is corrected or the increased requirement no longer exists. Pyridoxine may reduce the therapeutic effect of levodopa in patients with Parkinson’s disease. Riboflavin may cause urine to appear yellow. During treatment with this capsule, urine sugar tests using Benedict’s reagent may produce false-positive results because of the presence of ascorbic acid. Therefore, alternative testing methods not affected by ascorbic acid should be used.

Specific combined vitamin preparations

Store in a cool and dry place, protected from light and away from children.