This combination capsule is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Joint pain and inflammation
• Difficulty in flexibility and mobility
• Joint discomfort and stiffness (including reduced knee extension)

Each capsule contains:

• Undenatured Type-II Collagen 20 mg
• Hyaluronic Acid 35 mg
• Methylsulfonylmethane (MSM) 200 mg
• Turmeric Extract 50 mg (18% curcuminoids)
• Boswellia serrata Extract 50 mg (30% AKBA)

Undenatured Type II Collagen is derived from chicken sternum cartilage using a patented low-temperature, non-enzymatic process that preserves its natural triple-helix structure and biological activity.

It contains active binding sites called epitopes that initiate oral tolerization. In this process, the epitopes interact with Peyer’s patches in the small intestine and stimulate the release of collagen-specific regulatory T-cells. These cells migrate to joint tissues and help suppress harmful T-cell activity responsible for cartilage damage. It also reduces macrophage-mediated release of collagenase enzymes and decreases inflammatory cytokine production, thereby reducing inflammation, slowing cartilage degeneration, and supporting cartilage repair.

Hyaluronic acid is naturally present in the human body and plays an important role in joint function. It provides lubrication by forming a viscous, gel-like fluid that also acts as a shock absorber. It supports cartilage and bone growth by promoting new cell formation and helps reduce inflammation and pain caused by injury or degeneration.

Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant properties. Sulfur, a key component of MSM, is essential for the formation of collagen and glucosamine, which are important for healthy bones and joints. Clinical studies show that MSM significantly improves pain and physical function scores in osteoarthritis patients.

Turmeric extract contains curcumin, which has anti-inflammatory, antioxidant, antithrombotic, and antimicrobial activities. It works by inhibiting inflammatory mediators such as prostaglandins, leukotrienes, and cyclooxygenase-2 (COX-2). Curcumin also suppresses pro-inflammatory cytokines including TNF-α, IL-1, IL-8, and nitric oxide synthase.

Boswellia serrata contains boswellic acids, which have strong anti-inflammatory effects. The active compound 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) inhibits the enzyme 5-lipoxygenase (5-LOX), helping reduce inflammation in conditions such as rheumatoid arthritis.

One capsule two times daily with meal or as directed by the physician. The safety and effectiveness under the age of 18 years have not been established.

There is no known significant drug interaction with Undenatured Type II Collagen, Hyaluronic Acid, Methylsulfonylmethane, Turmeric Extract, and Boswellia serrata Extract.

This combination is contraindicated in patients with known hypersensitivity to Undenatured Type II Collagen, Hyaluronic Acid, Methylsulfonylmethane, Turmeric Extract, or Boswellia serrata Extract.

These ingredients are generally well tolerated at the recommended dose. Side effects are rare; however, some patients may experience mild gastric discomfort.

No adequate studies are available regarding the use of Undenatured Type II Collagen, Hyaluronic Acid, Methylsulfonylmethane, Turmeric Extract, and Boswellia serrata Extract during pregnancy and lactation. It should be used only under medical advice.

Drugs for Osteoarthritis, Herbal and Nutraceuticals, Specific mineral preparations

Store in a cool and dry place below 30°C, protected from direct sunlight and moisture. Keep out of the reach of children.