Promethazine Theoclate is an anti-emetic medication used to prevent and treat nausea and vomiting, including motion sickness and vertigo. These tablets contain promethazine, which is part of a class of medicines known as phenothiazines. Your doctor may prescribe this medicine for dizziness, light-headedness (vertigo), or post-operative sickness. The tablets should be taken exactly as directed by your physician.

Promethazine Theoclate works by blocking histamine from binding to its receptors in the brain’s vomiting centre, which controls feelings of nausea and the vomiting reflex.The vomiting centre is activated when it receives nerve signals from the vestibular apparatus in the middle ear, which constantly informs the brain about the body’s position.

When the vestibular apparatus is disturbed—such as during motion in a boat or car—it sends signals to the vomiting centre, leading to motion sickness symptoms like nausea, dizziness, vertigo (spinning sensation), and vomiting.

By blocking histamine receptors in the vomiting centre, Promethazine Theoclate prevents these signals from triggering nausea and vomiting, effectively reducing motion sickness and vertigo.

Motion sickness: Adults: For prevention on long journeys: One 25 mg tablet each evening at bedtime, starting the day
before setting out, the duration of action is such that a second dose in 24 hours is not often necessary.

For prevention of motion sickness on short journeys: One 25 mg tablet one or two hours before traveling or as soon after as possible.

Treatment of motion sickness: One 25mg tablet as soon as possible and repeated the same evening followed by a third tablet on the following evening.

Nausea and vomiting due to other causes: Adults: One 25mg tablet at night is often sufficient, but two or three tablets are sometimes necessary. Alternatively, more frequent administration such as 25mg two or three times a day may be required for some patients. is not often necessary to give more than four of the 25mg Avomine tablets in 24 hours.

Children: In the above indications children over 10 years of age may be given the lower adult doses described above. Children between 5 and 10 years may be given half the adults dose.

Elderly: No specific dosage recommendations

Promethazine Theoclate may increase the effects of anticholinergic agents, tricyclic antidepressants, sedatives, or hypnotics. Alcohol should be avoided during treatment. This medicine may interfere with urine-based immunologic pregnancy tests, potentially causing false-positive or false-negative results.

Before performing skin allergy tests with allergen extracts, Promethazine Theoclate should be stopped at least 72 hours prior, as it may suppress the skin’s histamine response, leading to false-negative results. In cases of nausea and vomiting of unknown cause, it is important to diagnose the underlying condition before giving this antiemetic, to avoid masking serious illnesses.

• Children under 2 years should not be given this medicine.
• Avoid if allergic to promethazine, any phenothiazine, or any ingredients in the medicine.
• Do not use if you have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days.
• Caution in patients with CNS depression, as it may cause drowsiness or unconsciousness.

Special care is needed if you have:

• Glaucoma
• Epilepsy
• Heart disease
• Liver problems
• Kidney or bladder problems
• Respiratory conditions like asthma or bronchitis
• Severe headaches with blurred vision, severe stomach pain with vomiting, dizziness, balance problems, ringing in ears, or nausea
• Persistent cough
• Signs or history of Reye’s syndrome

Do not use Promethazine Theoclate for more than 7 days without consulting your doctor.

Side effects may occur in some patients and include drowsiness, dizziness, restlessness, headache, nightmares, fatigue, and disorientation. Anticholinergic effects such as blurred vision, dry mouth, and urinary retention may occasionally be seen, with elderly patients being particularly prone to these effects and associated confusion. Other possible reactions include loss of appetite, gastric irritation, palpitations, hypotension, arrhythmias, extrapyramidal symptoms, muscle spasms, and tic-like movements of the head and face. Rarely, serious reactions such as anaphylaxis, jaundice, and blood disorders including hemolytic anemia may occur. Photosensitivity reactions have also been reported, and patients are advised to avoid strong sunlight during treatment.

Use in Pregnancy: Epidemiological data and animal studies suggest that promethazine is generally safe during pregnancy; however, it should only be used when considered essential by a physician. The use of Avomine tablets is not recommended during the last two weeks before delivery due to the risk of irritability and excessive stimulation in the newborn.

Use in Lactation: Available evidence indicates that only small amounts of the drug are excreted in breast milk; however, there remains a risk of irritability and excitation in the infant. Patients who are ambulatory and using Avomine for the first time should avoid driving or operating machinery during the initial days of treatment until it is confirmed that they do not experience central nervous system effects such as dizziness, confusion, or disorientation.

Promethazine Theoclate tablets may cause drowsiness, dizziness, confusion, or disorientation, which can impair the ability to drive or operate machinery safely. Patients should avoid such activities until they understand how the medicine affects them and are confident that their performance is not impaired. If children experience these effects, they should avoid potentially hazardous activities such as cycling, and should not be left unattended after taking the medication.

Alcohol should be avoided while taking Promethazine Theoclate, as it may intensify these effects.

This medicine may also increase sensitivity to sunlight, so direct exposure to sunlight or sunlamps should be avoided until individual sensitivity is known. If exposure is unavoidable, protective clothing or sunscreen should be used.

Promethazine Theoclate may interfere with certain pregnancy tests, potentially causing false positive or false negative results.

Before undergoing skin prick tests for allergy diagnosis, this medication should be discontinued at least 72 hours in advance, as antihistamines can suppress skin reactions and lead to unreliable test results.

Severe overdose symptoms can vary widely. In children, they may include combinations of excitation, ataxia, lack of coordination, athetosis, and hallucinations, while adults may experience marked drowsiness that can progress to coma. Convulsions may occur in both age groups and can be preceded by either excitement or coma. Cardiorespiratory depression is relatively uncommon. If the patient is assessed shortly after ingestion, vomiting may be induced with ipecacuanha despite promethazine’s antiemetic effect; alternatively, gastric lavage may be performed. Treatment is mainly supportive, with careful monitoring and maintenance of adequate respiratory and circulatory function. Convulsions should be managed with diazepam or another appropriate anticonvulsant.

Anti-emetic drugs, Miscellaneous sedatives & hypnotics, Sedating Anti-histamine

Do not use after the expiration date. Keep all medicines out of reach of children. Use only with a prescription from a registered physician.