Inositols are important molecules involved in female fertility and the maintenance of physiological pregnancy. Myo-inositol is the most abundant inositol isomer in the human body and is widely distributed in tissues such as the brain, blood, adipose tissue, kidneys, lungs, ovaries, and testes, where it participates in multiple cellular signaling pathways.
As a second messenger of gonadotropins and insulin, Myo-inositol plays a key role in normal oocyte development and embryogenesis. Clinical evidence suggests that Myo-inositol supplementation improves the chances of pregnancy and reduces adverse maternal and neonatal outcomes. It helps restore ovulation and normal menstrual cycles in infertile women, especially those with PCOS. It is also beneficial in assisted reproductive technology (ART) by improving oocyte and embryo quality. During pregnancy, it may reduce the risk of gestational diabetes mellitus (GDM), thereby lowering the risk of miscarriage and stillbirth. Additionally, it may help reduce neural tube defects (NTDs), particularly in folate-resistant cases.