Nabumetone is indicated for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. The potential benefits and risks should be carefully evaluated before initiating therapy, along with other available treatment options. The lowest effective dose should be used for the shortest duration consistent with individual patient treatment goals.

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. Although its exact mechanism of action is not fully understood, inhibition of prostaglandin synthesis is believed to play a key role in its anti-inflammatory effect. Nabumetone is a prodrug that undergoes hepatic metabolism to form its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which is a potent inhibitor of prostaglandin synthesis.

Nabumetone 500 mg & 750 mg Tablet: Oral Nabumetone 1000 mg Tablet: Mix 1 tablet thoroughly in a glass (250 ml) of pure water and drink it completely.

Osteoarthritis and Rheumatoid Arthritis: The recommended starting dose is 1000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1500 mg to 2000 mg per day. Nabumetone can be given in either a single or twice-daily dose. Dosages greater than 2000 mg per day have not been studied. The lowest effective dose should be used for chronic treatment.

Moderate or severe renal insufficiency: Caution should be taken in prescribing Nabumetone to patients with moderate or severe renal insufficiency. The maximum starting doses of Nabumetone in patients with moderate or severe renal insufficiency should not exceed 750 mg or 500 mg, respectively once daily. Following careful monitoring of renal function in patients with moderate or severe renal insufficiency, daily doses may be increased to a maximum of 1500 mg and 1000 mg, respectively.

Use in pediatric patients: Safety and effectiveness in pediatric patients have not been established.

Reports suggest that NSAIDs may reduce the antihypertensive effect of ACE inhibitors. This interaction should be considered in patients receiving concomitant therapy with NSAIDs and ACE inhibitors.

Nabumetone is contraindicated in patients with known hypersensitivity to nabumetone or any of its excipients. It should not be used in patients who have experienced asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs. Severe and rarely fatal anaphylactoid reactions have been reported in such cases. It is also contraindicated for peri-operative pain management in coronary artery bypass graft (CABG) surgery.

Gastrointestinal: diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, vomiting, gastritis, stomatitis, dry mouth, positive stool guaiac

CNS: dizziness, headache, fatigue, insomnia, nervousness, somnolence, increased sweating

Dermatologic: rash, pruritus

Special senses: tinnitus

Others: edema

Pregnancy Category C. There are no adequate well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed. Use during the third trimester is not recommended due to risk of premature closure of ductus arteriosus. It is not recommended during lactation due to potential adverse effects on the infant.

Long-term NSAID use may cause renal papillary necrosis and other kidney damage. Patients with reduced renal blood flow, heart failure, liver dysfunction, those taking diuretics, and elderly patients are at higher risk. NSAID-induced reduction in prostaglandin synthesis may lead to decreased renal perfusion and renal decompensation. Discontinuation usually leads to recovery.

Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, and drowsiness. Severe cases may present with gastrointestinal bleeding, hypertension, renal failure, respiratory depression, or coma. Treatment is supportive; there is no specific antidote. Activated charcoal and gastric lavage may be used if early ingestion is detected. Hemodialysis is not effective due to high protein binding.

Drugs for osteoarthritis / Drugs for rheumatoid arthritis

Store in a cool, dry place away from light and moisture. Keep all medicines out of reach of children.